Tributyrin

Base Information Edit

Chemical Name:Tributyrin
CAS No.:60-01-5
Molecular Formula:C15H26O6
Molecular Weight:302.368
Hs Code.:29171900
European Community (EC) Number:200-451-5
NSC Number:661583
UNII:S05LZ624MF
DSSTox Substance ID:DTXSID4052267
Nikkaji Number:J4.798H
Wikipedia:Tributyrin
Wikidata:Q4116129
NCI Thesaurus Code:C1260
Metabolomics Workbench ID:153649
ChEMBL ID:CHEMBL118722
Mol file:60-01-5.mol

Synonyms:glyceryl tributyrate;tributyrin;tributyrylglycerol

Suppliers and Price of Tributyrin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Glycerol Tributyrate
25ml
$ 256.00

TRC
Tributyrin
50g
$ 95.00

TCI Chemical
Tributyrin >98.0%(GC)
25mL
$ 29.00

TCI Chemical
Tributyrin >98.0%(GC)
500mL
$ 212.00

Sigma-Aldrich
Tributyrin 97%, FG
10kg
$ 509.00

Sigma-Aldrich
Tributyrin 97%, FG
5kg
$ 385.00

Sigma-Aldrich
Glyceryl tributyrate ≥99%
100ml
$ 184.00

Sigma-Aldrich
Tributyrin 97%, FG
1kg
$ 111.00

Sigma-Aldrich
Glyceryl tributyrate puriss., ≥98.5% (GC)
100ml
$ 75.00

Sigma-Aldrich
Glyceryl tributyrate analytical standard
1ml
$ 64.10

Total 94 raw suppliers

Chemical Property of Tributyrin Edit

Chemical Property:

Appearance/Colour:colourless liquid
Vapor Pressure:0.000722mmHg at 25°C
Melting Point:-75 °C
Refractive Index:n20/D 1.435(lit.)
Boiling Point:307.499 °C at 760 mmHg
Flash Point:143.415 °C
PSA：78.90000
Density:1.054 g/cm³
LogP:2.38490
Storage Temp.:Store at RT.
Solubility.:H2O: insoluble
Water Solubility.:Not miscible in water.
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:14
Exact Mass:302.17293854
Heavy Atom Count:21
Complexity:304

Purity/Quality:

99% ^*data from raw suppliers

Glycerol Tributyrate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC
Recent ClinicalTrials:Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Tributyrin Supplementation
Description Tributyrin (C15H26O6), also known as butyrin or glyceryl tributyrate, is the triester of glycerin and butyric acid. It is prepared by esterifcation of glycerin with excess butyric acid. Glycerol tributyrate has a characteristic odor and a bitter taste.Tributyrin is essentially a triacylglyceride (TAG), which is an ester derived from glycerol and 3 fatty acids. Tributyrin requires lipase to release the butyrate attached to the glycerol. Although 1 tributyrin contains 3 butyrate, not all 3 butyrate is guaranteed to be released. This is because lipase is regioselective. It can hydrolyse triacylglycerides at R1 and R3, only R2, or non-specifically. Lipase also has substrate specificity in that the enzyme can differentiate between acyl chains attached to the glycerol and preferentially cleaving certain types. Since tributyrin requires lipase to release its butyrate, there may be competition between tributyrin and other TAGs for lipase.
Uses Tributyrin is a stable and rapidly absorbed prodrug of butyric acid which enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells. Tributyrin is a flavoring agent that is the triester of glycerin and butyric acid. it is prepared by esterification of glycerin with excess butyric acid. it is used in the following foods: baked goods; alcoholic beverages; nonalcoholic beverages; fats and oils; frozen dairy des- serts and mixes; gelatins, puddings and fillings; and soft candy. it is also termed butyrin and glyceryl tributyrate.

Technology Process of Tributyrin

There total 13 articles about Tributyrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.49%

: 56-81-5,25618-55-7,64333-26-2,8013-25-0
glycerol

: 107-92-6
butyric acid

: 60-01-5
tributyrin

Guidance literature:: With phosphoric acid; aminosulfonic acid; at 100 ℃; for 12h; Reagent/catalyst; Temperature; Catalytic behavior; Green chemistry;