Perazine

Base Information

• Chemical Name: Perazine
• CAS No.: 84-97-9
• Molecular Formula: C20H25 N3 S
• Molecular Weight: 339.505
• Hs Code.: 2934300000
• European Community (EC) Number: 201-578-9
• NSC Number: 638694
• UNII: 8915147A2B
• DSSTox Substance ID: DTXSID6048628
• Nikkaji Number: J9.873F
• Wikipedia: Perazine
• Wikidata: Q392481
• NCI Thesaurus Code: C81093
• Metabolomics Workbench ID: 60413
• ChEMBL ID: CHEMBL1697766
• Mol file: 84-97-9.mol

Synonyms:Dihydrochloride, Perazine;Maleate, Perazine;Perazine;Perazine Dihydrochloride;Perazine Maleate;Perazine Maleate (1:1);Perazine Maleate (1:2);Pernazine;Taxilan

Chemical Property of Perazine

Chemical Property:

• Vapor Pressure: 6.91E-10mmHg at 25°C
• Melting Point: 51-53oC
• Refractive Index: 1.5605 (estimate)
• Boiling Point: 493.6°C at 760 mmHg
• PKA: 7.66±0.10(Predicted)
• Flash Point: 252.3°C
• PSA: 35.02000
• Density: 1.149g/cm³
• LogP: 3.86760
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 339.17691898
• Heavy Atom Count: 24
• Complexity: 374

Purity/Quality:

99.9% ^*data from raw suppliers

Perazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=CC=CC=C42
• Recent ClinicalTrials: Evaluation of the Necessity of Long-term Pharmacological Treatment With Antipsychotics in Schizophrenic Patients
• Recent EU Clinical Trials: English: Are Antipsychotics Neurotoxic or Neuroprotective? A Randomised Multicentre Longitudinal Study for Comparison of Two Therapy Strategies for the Treatment of Schizophrenia.
• Uses: Antipsychotic.

Technology Process of Perazine

There total 17 articles about Perazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-methyl-piperazine (109-01-3) + 10-(3-chloropropyl)-10H-phenothiazine (5909-59-1) → Perazin (84-97-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide; at 150 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.12.042

Reference yield: 81.4%

→ Perazin (84-97-9)

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; Reflux;

Reference yield: 78.0%

β-(10-phenothiazinyl)propion-4-methylpiperazide (91508-47-3) → 3-(10H-phenothiazin-10-yl)propan-1-ol (63397-92-2) + Perazin (84-97-9)

Guidance literature:

With borane; In tetrahydrofuran; 1.) 25 deg C, 1 h; 2.) reflux, 6 h;

upstream raw materials:

3-(N-methylpiperazinyl)propyl chloride

10H-phenothiazine

1-methyl-piperazine

10-(3-bromopropyl)phenothiazine

Downstream raw materials:

Perazin-4-benzylbromid

Perazin-4-methyliodid

Perazin-1,4-dimethyliodid

Perazin-1-methyl-4-benzyl-dichlorid

Refernces

• 1、 Scalacci, Nicolò,Brown, Alistair K.,Pavan, Fernando R.,Ribeiro, Camila M.,Manetti, Fabrizio,Bhakta, Sanjib,Maitra, Arundhati,Smith, Darren L.,Petricci, Elena,Castagnolo, Daniele. "Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis". . p. 147 - 158. Retrieved 2016/12/30.
• 2、 Brufani,Cesta,Filocamo,Lappa,Marta,Pomponi,Meroni,Pagella. "Synthesis of phenothiazine derivatives as potential inhibitors of phospholipase C". . p. 585 - 597. Retrieved 2007/10/02.