C₂₃H₂₁Cl₂FN₆O

Base Information

• Chemical Name: C₂₃H₂₁Cl₂FN₆O
• CAS No.: 1394930-43-8
• Molecular Formula: C₂₃H₂₁Cl₂FN₆O
• Molecular Weight: 487.364
• Mol file: 1394930-43-8.mol

Synonyms:C₂₃H₂₁Cl₂FN₆O

Chemical Property of C₂₃H₂₁Cl₂FN₆O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₁Cl₂FN₆O

There total 8 articles about C₂₃H₂₁Cl₂FN₆O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C28H29Cl2FN6O3 (1394930-41-6) → C23H21Cl2FN6O (1394930-43-8)

Guidance literature:

C₂₈H₂₉Cl₂FN₆O₃; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium carbonate; In dichloromethane;

DOI:10.1016/j.bmc.2012.07.007

Reference yield:

2',6'-dichloro-3'-fluoroacetophenone (290835-85-7) → C23H21Cl2FN6O (1394930-43-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

2.1: triethylamine; dmap / dichloromethane / 1 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

3.2: 4 h / 80 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate / water; ethanol; 1,2-dimethoxyethane / 0.83 h / 110 °C / Microwave irradiation

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With dmap; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; sodium hydride; triethylamine; trifluoroacetic acid; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 4.1: |Suzuki Coupling;

DOI:10.1016/j.bmc.2012.07.007

Reference yield:

6-bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-3H,4H-pyrido[2,3-d]pyrimidin-4-one (1394930-38-1) → C23H21Cl2FN6O (1394930-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate / water; ethanol; 1,2-dimethoxyethane / 0.83 h / 110 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1: |Suzuki Coupling;

DOI:10.1016/j.bmc.2012.07.007

upstream raw materials:

6-bromo-3H,4H-pyrido[2,3-d]pyrimidin-4-one

C₂₈H₂₉Cl₂FN₆O₃

2-aminopyridin-3-carboxylic acid

2',6'-dichloro-3'-fluoroacetophenone

Refernces