2-HYDROXY-6-METHYL-4-PHENYL-1,4-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-HYDROXY-6-METHYL-4-PHENYL-1,4-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 5395-36-8
• Molecular Formula: C₁₄H₁₆N₂O₃
• Molecular Weight: 260.293
• Hs Code.: 2933599090
• Mol file: 5395-36-8.mol

Synonyms:1,2,3,4-Tetrahydro-6-methyl-2-oxo-4-phenyl-5-Pyrimidinecarboxylicacid ethyl ester;5-(Ethoxycarbonyl)-4-phenyl-6-methyl-3,4-dihydropyrimidin-2(1H)-one;5-Ethoxycarbonyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one;6-Methyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethylester;Ethyl 2-hydroxy-6-methyl-4-phenyl-3,4-dihydropyrimidine-5-carboxylate;NSC 14857;NSC 24338;NSC 2780;NSC 5975;

Chemical Property of 2-HYDROXY-6-METHYL-4-PHENYL-1,4-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 3.57E-06mmHg at 25°C
• Melting Point: 202-203 °C
• Refractive Index: 1.537
• Boiling Point: 386.34 °C at 760 mmHg
• PKA: 11.34±0.70(Predicted)
• Flash Point: 187.452 °C
• PSA: 70.92000
• Density: 1.169 g/cm³
• LogP: 1.84640
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylicAcid,EthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic Acid, Ethyl Ester (cas# 5395-36-8) is a compound useful in organic synthesis.

Technology Process of 2-HYDROXY-6-METHYL-4-PHENYL-1,4-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER

There total 63 articles about 2-HYDROXY-6-METHYL-4-PHENYL-1,4-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl acetoacetate (141-97-9) + benzaldehyde (100-52-7) + urea (57-13-6) → ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate (123237-03-6,5395-36-8)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In ethanol; at 100 ℃; for 1h; Microwave irradiation; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.10.150

Reference yield: 97.0%

ethyl acetoacetate (141-97-9) + urea (57-13-6) + benzyl alcohol (100-51-6,185532-71-2) → ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate (123237-03-6,5395-36-8)

Guidance literature:

benzyl alcohol; With bismuth(III) nitrate; In various solvent(s); at 50 ℃; for 0.0833333h;

ethyl acetoacetate; urea; In various solvent(s); at 90 ℃;

DOI:10.3987/COM-04-10257

Reference yield: 97.0%

benzylidene 1,1-diacetate (581-55-5) + ethyl acetoacetate (141-97-9) + urea (57-13-6) → ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate (123237-03-6,5395-36-8)

Guidance literature:

With bismuth(III) nitrate; at 100 ℃; for 0.166667h;

DOI:10.1002/hc.20352

upstream raw materials:

ethanol

5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione

chloroacetic acid

ethyl acetoacetate

Downstream raw materials:

5-ethoxycarbonyl-3,6-dimethyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

4-cyclohexyl-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

5-ethoxycarbonyl-6-methyl-3-benzoyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

ethyl 1,2,3,4-tetrahydro-2-oxo-4-phenyl-6-propylpyrimidine-5-carboxylate

Refernces

• 1、 Sadjadi, Samahe,Koohestani, Fatemeh. "Composite of cross-linked chitosan beads and a cyclodextrin nanosponge: A metal-free catalyst for promoting ultrasonic-assisted chemical transformations in aqueous media". . . Retrieved 2021/05/17.
• 2、 Patel, Dikin,Modi, Chetan K.,Jha, Prafulla K.,Srivastava, Himanshu,Kane, Sanjeev R.. "ZnO Nanoparticles Embedded on a Reduced Graphene Oxide Nanosheet (ZnO?NPs@r-GO) as a Proficient Heterogeneous Catalyst for a One-Pot A3-Coupling Reaction". supporting information. p. 3578 - 3590. Retrieved 2021/09/09.