3α-(p-aminomethyl)phenyl-7α,12α-diacetoxycholan-24-oic acid

Base Information

• Chemical Name: 3α-(p-aminomethyl)phenyl-7α,12α-diacetoxycholan-24-oic acid
• CAS No.: 125627-00-1
• Molecular Formula: C₃₅H₅₁NO₆
• Molecular Weight: 581.793
• Mol file: 125627-00-1.mol

Synonyms:3α-(p-aminomethyl)phenyl-7α,12α-diacetoxycholan-24-oic acid

Chemical Property of 3α-(p-aminomethyl)phenyl-7α,12α-diacetoxycholan-24-oic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3α-(p-aminomethyl)phenyl-7α,12α-diacetoxycholan-24-oic acid

There total 6 articles about 3α-(p-aminomethyl)phenyl-7α,12α-diacetoxycholan-24-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 7α,12α-diacetoxy-3α-cholan-24-oate (125626-98-4) → 3α-(p-aminomethyl)phenyl-7α,12α-diacetoxycholan-24-oic acid (125627-00-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; for 5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)80185-X

Reference yield:

methyl 3-keto-7,12-diacetylcholate (4947-65-3) → 3α-(p-aminomethyl)phenyl-7α,12α-diacetoxycholan-24-oic acid (125627-00-1)

Guidance literature:

Multi-step reaction with 2 steps

2: 90 percent / NaOH / methanol; tetrahydrofuran

With sodium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1039/c39890001050

Reference yield:

methyl cholate (1448-36-8) → 3α-(p-aminomethyl)phenyl-7α,12α-diacetoxycholan-24-oic acid (125627-00-1)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine, dimethylaminopyridine (DMAP)

2: AcCl / methanol

3: pyridinium chlorochromate

5: 90 percent / NaOH / methanol; tetrahydrofuran

With pyridine; dmap; sodium hydroxide; acetyl chloride; pyridinium chlorochromate; In tetrahydrofuran; methanol;

DOI:10.1039/c39890001050

upstream raw materials:

methyl 7α,12α-diacetoxy-3α-cholan-24-oate

cholic acid

methyl 7,12-diacetoxycholate

methyl 3-keto-7,12-diacetylcholate

Downstream raw materials:

pentafluorophenyl 7α,12α-diacetoxy-3α-(p-tert-butoxycarbonylaminomethylphenyl)cholan-24-oate

7α,12α-diacetoxy-3α-(p-tert-butoxycarbonylaminomethylphenyl)cholan-24-oic acid

Refernces

• 1、 Bonar-Law, Richard,Davis, Anthony P.. "Synthesis of Steroidal Cyclodimers from Cholic Acid; a Molecular Framework with Potential for Recognition and Catalysis". . p. 1050 - 1052. Retrieved 2007/10/02.