2-Amino-4-chlorobenzenesulfonamide

Base Information

• Chemical Name: 2-Amino-4-chlorobenzenesulfonamide
• CAS No.: 4140-83-4
• Molecular Formula: C6H7 Cl N2 O2 S
• Molecular Weight: 206.653
• Hs Code.: 2935009090
• European Community (EC) Number: 223-965-1
• NSC Number: 25856
• DSSTox Substance ID: DTXSID20194334
• Nikkaji Number: J224.945F
• Wikidata: Q83067101
• ChEMBL ID: CHEMBL506160
• Mol file: 4140-83-4.mol

Synonyms:2-Amino-4-chlorobenzenesulfonamide;4140-83-4;2-Amino-4-chlorobenzenesulphonamide;2-amino-4-chlorobenzene-1-sulfonamide;2-Amino-4-chlorobenzene sulfonamide;EINECS 223-965-1;NSC25856;CHEMBL506160;SCHEMBL1463352;DTXSID20194334;4-chloro-2-aminobenzenesulfonamide;2-amino-4-chloro-benzenesulfonamide;GS0961;NSC 25856;NSC-25856;AKOS009227154;Benzenesulfonamide, 2-amino-4-chloro-;SB77567;CS-0112557;EN300-59491;D77080;Z359331366

Chemical Property of 2-Amino-4-chlorobenzenesulfonamide

Chemical Property:

• Vapor Pressure: 2.9E-07mmHg at 25°C
• Melting Point: 144-146 °C
• Boiling Point: 420°Cat760mmHg
• PKA: 10.10±0.60(Predicted)
• Flash Point: 207.8°C
• PSA: 94.56000
• Density: 1.558g/cm³
• LogP: 2.93190
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 205.9916763
• Heavy Atom Count: 12
• Complexity: 249

Purity/Quality:

99% ^*data from raw suppliers

2-amino-4-chlorobenzene-1-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)N)S(=O)(=O)N

Technology Process of 2-Amino-4-chlorobenzenesulfonamide

There total 2 articles about 2-Amino-4-chlorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chloro-2-nitrobenzene-1-sulfonamide (13852-81-8) → 2-amino-4-chlorobenzenesulfonamide (4140-83-4)

Guidance literature:

With hydrogen iodide; at 90 ℃; for 2h;

DOI:10.1016/S0040-4039(01)01083-8

Reference yield:

→ 2-amino-4-chlorobenzenesulfonamide (4140-83-4)

Guidance literature:

d. Nitroverb., H2/Pd-C/A.;

DOI:10.1021/ja01490a029

Reference yield: 100.0%

(E)-2-(4-(difluoromethoxy)phenyl)ethenesulfonyl chloride (1161945-31-8) + 2-amino-4-chlorobenzenesulfonamide (4140-83-4) → (E)-4-Chloro-2-(2-(4-(difluoromethoxy)phenyl)vinylsulfonamido)benzenesulfonamide (1161945-88-5)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

upstream raw materials:

4-chloro-2-nitrobenzene-1-sulfonamide

Downstream raw materials:

(6-chloro-1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-phenyl-amine

5'-Chloro-2'-sulfamoyloxanilic acid ethyl ester

8-chloro-2,2,3a-trimethyl-5,5-dioxo-4,5-dihydro-3aH-benzo[e]oxazolo[2,3-c][1,2,4]thiadiazin-1-one

6-chloro-3-chloromethyl-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

Refernces

• 1、 TOPLISS,SHERLOCK,REIMANN,KONZELMAN,SHAPIRO,PETTERSEN,SCHNEIDER,SPERBER. "ANTIHYPERTENSIVE AGENTS. I. NON-DIURETIC 2H-1,2,4-BENZOTHIADIAZINE". . p. 122 - 127. Retrieved 2007/10/05.