(S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide

Base Information

• Chemical Name: (S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide
• CAS No.: 851513-48-9
• Molecular Formula: C₁₂H₁₄F₃NOS
• Molecular Weight: 277.31
• Mol file: 851513-48-9.mol

Synonyms:(S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide

Chemical Property of (S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide

There total 1 articles about (S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → (S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide (851513-48-9)

Guidance literature:

With titanium(IV) tetraethanolate; In tetrahydrofuran; at 20 ℃; for 19h;

DOI:10.1016/j.tet.2008.04.060

Reference yield: 99.0%

trifluoromethan (75-46-7) + (S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide (851513-48-9) → (S)-2-methyl-N-((R)-2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethyl)propane-2-sulfinamide

Guidance literature:

trifluoromethan; (S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide; In toluene; at -78 ℃; for 0.25h; Glovebox; Inert atmosphere;

With phosphazene base-P₄-tert-butyl; In hexane; at -78 ℃;

Reference yield: 91.0%

3-fluoro-3-(2,2,2-trifluoro-1,1-dihydroxyethyl)-1,3-dihydroindole-2-one + (S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide (851513-48-9) → C20H20F4N2O2S

Guidance literature:

With triethylamine; lithium bromide; In acetonitrile; at 0 ℃; for 0.166667h; diastereoselective reaction;

DOI:10.1039/c6ra27710a

upstream raw materials:

4-Trifluoromethylbenzaldehyde

(S)-2-methylpropane-2-sulfinamide

Refernces

• 1、 Chogii, Isaac,Das, Pradipta,Delost, Michael D.,Crawford, Mark N.,Njardarson, Jon T.. "Asymmetric Vinylogous Aza-Darzens Approach to Vinyl Aziridines". supporting information. p. 4942 - 4945. Retrieved 2018/08/24.