Pavulon

Base Information

• Chemical Name: Pavulon
• CAS No.: 15500-66-0
• Molecular Formula: 2Br*C₃₅H₆₀N₂O₄
• Molecular Weight: 732.68
• Hs Code.: 2933399090
• European Community (EC) Number: 239-532-5
• Wikipedia: Pancuronium_bromide
• NCI Thesaurus Code: C47651
• RXCUI: 7884
• Mol file: 15500-66-0.mol

Synonyms:Bromide, Pancuronium;Pancuronium;Pancuronium Bromide;Pancuronium Curamed;Pancuronium Organon;Pavulon

Chemical Property of Pavulon

Chemical Property:

• Appearance/Colour: White powder
• Melting Point: 214 - 217oC
• Boiling Point: ~100°C
• PSA: 52.60000
• Density: ~1, mp: 0°C
• LogP: 0.03610
• Storage Temp.: Desiccate at RT
• Solubility.: Very soluble or freely soluble in water, very soluble in methylene chloride, freely soluble in ethanol (96 per cent).
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 651.37365
• Heavy Atom Count: 42
• Complexity: 1000

Purity/Quality:

99%min ^*data from raw suppliers

Pancuronium dibromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OC1CC2CCC3C(C2(CC1[N+]4(CCCCC4)C)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-]
• Isomeric SMILES: CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1[N+]4(CCCCC4)C)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-]
• Description: Pancuronium bromide, a bisquaternary amine and the first steroid N MBA used clinically, was developed by Savege and Hewitt and marketed in 1964. The intubating dose is 0.1mgkg–1, which takes 3-4min to reach its maximum effect. The clinical duration of action of the drug is long, especially in the presence of potent inhalational agents or renal dysfunction, as 60% of a dose of the drug is excreted unchanged through the kidneys. I t is also deacetylated in the liver; some of the metabolites have neuromuscular blocking properties.Pancuronium does not stimulate histamine release; however, it has direct vagolytic and sympathomimetic effects which may cause tachycardia and hypertension. It slightly inhibits plasma cholinesterase and therefore potentiates any drug metabolised by this enzyme, such as suxamethonium and mivacurium.
• Uses: Pancuronium is a steroid compound that does not possess hormonal activity. It is used in anesthesiology as a myorelaxant, causing prolonged muscle relaxation during surgical interventions of the thoracic and abdominal cavities, in proctology, ophthalmology, orthopedic practice, and in heart surgeries. A synonym of this drug is pavulon. Pancuronium Bromide has been used as an analgesic in various experiments. A potent steroidal neuromuscular blocking agent; muscle relaxant. progestinantineoplastic
• Therapeutic Function: Muscle relaxant
• Biological Functions: Pancuronium bromide (Pavulon) is a synthetic bisquaternary agent containing a steroid nucleus (amino steroid), as denoted by the -curonium suffix. It is five times as potent as d-tubocurarine. Unlike d-tubocurarine, it does not release histamine or block ganglionic transmission. Like d-tubocurarine, it has a moderately long onset (2.9 minutes) and duration of action (110 minutes). Pancuronium and its metabolite are eliminated in the urine.
• Clinical Use: As indicated, the principal use of pancuronium bromideis as an adjunct to anesthesia, to induce relaxation of skeletalmuscle, but it is also used to facilitate the managementof patients undergoing mechanical ventilation. Only experiencedclinicians equipped with facilities for applyingartificial respiration should administer it, and the dosageshould be adjusted and controlled carefully.
• Drug interactions: Potentially hazardous interactions with other drugs Anaesthetics: enhanced muscle relaxant effect. Anti-arrhythmics: procainamide enhances muscle relaxant effect. Antibacterials: effect enhanced by aminoglycosides, clindamycin, polymyxins and piperacillin. Antiepileptics: muscle relaxant effects antagonised by carbamazepine; effects reduced by long-term use of fosphenytoin and phenytoin but might be increased by acute use. Botulinum toxin: neuromuscular block enhanced (risk of toxicity).

Technology Process of Pavulon

There total 5 articles about Pavulon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

methyl bromide (74-83-9) + (2β,3α,5α,16β,17β)-2,16-bispiperidino-3,17-diacetoxy-androstane (13529-31-2) → pancuronium bromide (15500-66-0,50588-02-8)

Guidance literature:

In acetonitrile; at 40 ℃; for 96h;

Reference yield:

2,16-di(piperidin-1-yl)androstane-3,17-diol → pancuronium bromide (15500-66-0,50588-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 6 h / 100 - 110 °C

2: acetonitrile / 96 h / 40 °C

With acetic acid; In acetonitrile;

Reference yield:

→ C35H60N2O4(2+)*2Br(1-) (15500-66-0,50588-02-8)

Guidance literature:

Aus d. Stammverb. durch Alkyl.;

upstream raw materials:

methyl bromide

(2β,3α,5α,16β,17β)-2,16-bispiperidino-3,17-diacetoxy-androstane

Refernces