4-Methoxybenzenesulfonohydrazide

Base Information

• Chemical Name: 4-Methoxybenzenesulfonohydrazide
• CAS No.: 1950-68-1
• Molecular Formula: C7H10N2O3S
• Molecular Weight: 202.234
• Hs Code.: 29280000
• European Community (EC) Number: 217-769-5
• NSC Number: 267215
• UNII: JLC84M74XM
• DSSTox Substance ID: DTXSID10173158
• Nikkaji Number: J145.958I
• Wikidata: Q83043241
• Mol file: 1950-68-1.mol

Synonyms:4-Methoxybenzenesulfonohydrazide;1950-68-1;4-Methoxybenzenesulfonyl hydrazide;p-Methoxyphenylsulfonylhydrazine;p-Methoxybenzenesulphonyl hydrazide;p-Methoxybenzenesulfonic acid hydrazide;BENZENESULFONIC ACID, 4-METHOXY-, HYDRAZIDE;p-Methoxyphenylsulfonyl hydrazide;4-Methoxybenzenesulfonic acid hydrazide;JLC84M74XM;4-Methoxybenzenesulphonohydrazide;p-Methoxybenzenesulfonic hydrazide;(p-Methoxybenzenesulfonyl)hydrazine;EINECS 217-769-5;NSC-267215;Benzenesulfonic acid, p-methoxy-, hydrazide;4-Methoxybenzenesulphonyl Hydrazide;4-methoxybenzene-1-sulfonohydrazide;UNII-JLC84M74XM;Cambridge id 5134043;Oprea1_846138;4-methoxybenzenesulonohydrazide;SCHEMBL419059;p-Methoxybenzenesulfonohydrazide;p-Methoxybenzenesulfonylhydrazide;4-methoxy benzenesulfonohydrazide;4-Methoxyphenylsulfonyl hydrazide;DTXSID10173158;CHEBI:188589;4-Methoxybenzenesulfonohydrazide #;AM9977;MFCD00014751;NSC267215;STK502512;AKOS001606710;NSC 267215;P-METHOXYBENZENESULFONYL HYDRAZIDE;Benzenesulfonic acid,4-methoxy-,hydrazide;PS-10336;(4-METHOXYBENZENESULFONYL)HYDRAZINE;CS-0150368;FT-0618916;D71252;EN300-7382512;J-012637

Chemical Property of 4-Methoxybenzenesulfonohydrazide

Chemical Property:

• Appearance/Colour: White Solid
• Vapor Pressure: 1.19E-05mmHg at 25°C
• Melting Point: 111-114 °C(lit.)
• Refractive Index: 1.564
• Boiling Point: 369.4 °C at 760 mmHg
• PKA: 9.27±0.10(Predicted)
• Flash Point: 177.2 °C
• PSA: 89.80000
• Density: 1.337 g/cm³
• LogP: 2.01920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 202.04121336
• Heavy Atom Count: 13
• Complexity: 239

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxybenzenesulfonohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)S(=O)(=O)NN

Technology Process of 4-Methoxybenzenesulfonohydrazide

There total 5 articles about 4-Methoxybenzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-phenyl-sulphonyl chloride (98-68-0) → 4-methoxybenzenesulfonyl hydrazide (1950-68-1)

Guidance literature:

With hydrazine hydrate; In tetrahydrofuran; at 0 ℃;

DOI:10.3390/md14050085

Reference yield:

C10H10N2O3S → 4-methoxybenzenesulfonyl hydrazide (1950-68-1)

Guidance literature:

With hydrazine hydrate; for 0.0166667h; Sonication;

Reference yield:

methoxybenzene (100-66-3) → 4-methoxybenzenesulfonyl hydrazide (1950-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1: HSO₃Cl / CHCl₃ / 0 °C

2: aq. N₂H₄ / benzene

With chlorosulfonic acid; hydrazine hydrate; In chloroform; benzene;

upstream raw materials:

4-methoxy-phenyl-sulphonyl chloride

methoxybenzene

4-methoxybenzenesulfonic acid

Downstream raw materials:

4-methoxy-benzenesulfonic acid-(N'-ξ-D-glucopyranosyl-hydrazide)

4-methoxy-benzenesulfonic acid (1-ethyl-9,10-dihydro-6H,8H-2-thia-6-aza-cycloocta[cd]inden-7-ylidene)-hydrazide

Se-phenyl 4-methoxybenzenesulfonoselenoate

3-(p-Methoxy-benzolsulfonhydrazono)-indanon-⁽¹⁾

Refernces

• 1、 Fernandes, Thais Batista,Segretti, Natanael Dante,Louren?o, Felipe Rebello,Candido, Thalita Marcílio,Baby, André Rolim,Barbosa, Euzébio Guimar?es,Parise-Filho, Roberto. "Design of arylsulfonylhydrazones as potential fabh inhibitors: Synthesis, antimicrobial evaluation and molecular docking". . p. 474 - 484. Retrieved 2021/03/26.
• 2、 Bourbon, Paul,Appert, Emeline,Martin-Mingot, Agnès,Michelet, Bastien,Thibaudeau, Sébastien. "Complementary Site-Selective Sulfonylation of Aromatic Amines by Superacid Activation". supporting information. p. 4115 - 4120. Retrieved 2021/06/21.