Atrial natriuretic factor (1-28) (human, porcine)

Base Information

• Chemical Name: Atrial natriuretic factor (1-28) (human, porcine)
• CAS No.: 91917-63-4
• Molecular Formula: C₁₂₇H₂₀₅N₄₅O₃₉S₃
• Molecular Weight: 3082.5
• DSSTox Substance ID: DTXSID70583193
• Mol file: 91917-63-4.mol

Synonyms:Atrial natriuretic factor (1-28) (human, porcine);DTXSID70583193;Atrial Natriuretic Peptide human, >=97% (HPLC);Alternative Name: Atrial Natriuretic Peptide (1-28) (human, porcine);Serylleucylarginylarginylserylserylcysteinylphenylalanylglycylglycylarginylmethionyl-alpha-aspartylarginylisoleucylglycylalanylglutaminylserylglycylleucylglycylcysteinylasparaginylserylphenylalanylarginyltyrosine

Chemical Property of Atrial natriuretic factor (1-28) (human, porcine)

Chemical Property:

• PSA: 1479.28000
• LogP: -2.10540
• Storage Temp.: −20°C
• XLogP3: -15.9
• Hydrogen Bond Donor Count: 55
• Hydrogen Bond Acceptor Count: 48
• Rotatable Bond Count: 109
• Exact Mass: 3081.4637002
• Heavy Atom Count: 214
• Complexity: 6900

Purity/Quality:

98%,99%, ^*data from raw suppliers

Atrial Natriuretic Peptide human ≥97% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CO)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=CC=C3)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)N
• Uses: Atrial natriuretic peptide (ANP) has been used to study its cross reactivity in melanin concentrating hormone (MCH) assay. It has also been used to study its effects in nerve fibres and nerve cell bodies.

Technology Process of Atrial natriuretic factor (1-28) (human, porcine)

There total 1 articles about Atrial natriuretic factor (1-28) (human, porcine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

C28H28NO5Pol + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-Leu-OH (35661-60-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + N-Fmoc L-Phe (35661-40-6) + Fmoc-Ser(tBu)-OH (71989-33-8) + Fmoc-(tBu)Asp-OH (71989-14-5) + Fmoc-Ile-OH (71989-23-6,251316-98-0) + N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine (103213-32-7,167015-11-4) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine (71989-28-1) + L-Asn(Trt) (132388-59-1) + Fmoc-L-Gln(Trt)-OH (132327-80-1,200623-62-7) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → atrial natriuretic peptide (91917-63-4)

Guidance literature:

C₂₈H₂₈NO₅Pol; TrtA-PEG-resin Automated synthesizer;

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; TrtA-PEG-resin Automated synthesizer;

N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Leu-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; N-Fmoc L-Phe; Fmoc-Ser(tBu)-OH; Fmoc-(tBu)Asp-OH; Fmoc-Ile-OH; N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine; L-Asn(Trt); Fmoc-L-Gln(Trt)-OH; Further stages;

upstream raw materials:

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Leu-OH

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

N-Fmoc L-Phe

Refernces