methyl 3-(3-(trifluoromethyl)phenyl)propanoate

Base Information

• Chemical Name: methyl 3-(3-(trifluoromethyl)phenyl)propanoate
• CAS No.: 294856-02-3
• Molecular Formula: C₁₁H₁₁F₃O₂
• Molecular Weight: 232.202
• Mol file: 294856-02-3.mol

Synonyms:methyl 3-(3-(trifluoromethyl)phenyl)propanoate

Chemical Property of methyl 3-(3-(trifluoromethyl)phenyl)propanoate

Chemical Property:

• Boiling Point: 232.9±35.0 °C(Predicted)
• Density: 1?+-.0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-(3-trifluoromethylphenyl)propanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(3-(trifluoromethyl)phenyl)propanoate

There total 14 articles about methyl 3-(3-(trifluoromethyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 3-(3-trifluoromethylphenyl)propanoic acid (585-50-2) → methyl 3-(3-(trifluoromethyl)phenyl)propanoate (294856-02-3)

Guidance literature:

With sulfuric acid; Reflux;

DOI:10.1002/anie.201609110

Reference yield: 95.0%

3-bromo-1-trifluoromethylbenzene (401-78-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-(3-(trifluoromethyl)phenyl)propanoate (294856-02-3)

Guidance literature:

3-bromo-1-trifluoromethylbenzene; acrylic acid methyl ester; With palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 110 ℃; for 15h; Inert atmosphere;

With hydrogen; at 20 ℃; for 15h; under 760.051 Torr;

DOI:10.1021/jo200023r

Reference yield: 92.0%

methyl m-trifluoromethylcinnamate (87087-35-2) → methyl 3-(3-(trifluoromethyl)phenyl)propanoate (294856-02-3)

Guidance literature:

With hydrazine hydrate; In acetonitrile; at 20 ℃; for 24h; Irradiation;

DOI:10.1002/ejoc.201403021

upstream raw materials:

3-(3-trifluoromethylphenyl)propanoic acid

diazomethyl-trimethyl-silane

methyl 2-bromo-3-(3-trifluoromethylphenyl)propionate

3-(trifluoromethyl)cinnamic acid

Downstream raw materials:

dimethyl 4-(3-trifluoromethylphenyl)-2-oxobutylphosphonate

3-(3-trifluoromethylphenyl)propanoic acid

(3aR,4R,5R,6aS)-5-Hydroxy-4-[(E)-(S)-3-hydroxy-5-(3-trifluoromethyl-phenyl)-pent-1-enyl]-hexahydro-cyclopenta[b]furan-2-one

Benzoic acid (3aR,4R,5R,6aS)-2-oxo-4-[(E)-3-oxo-5-(3-trifluoromethyl-phenyl)-pent-1-enyl]-hexahydro-cyclopenta[b]furan-5-yl ester

Refernces

• 1、 -. "Preparation method of cinacalcet hydrochloride and intermediate thereof". . . Retrieved 2020/06/09.
• 2、 Leow, Dasheng,Chen, Ying-Ho,Hung, Tzu-Hang,Su, Ying,Lin, Yi-Zhen. "Photodriven Transfer Hydrogenation of Olefins". . p. 7347 - 7352. Retrieved 2016/02/18.