N-benzyloxycarbonyl-4-methylpiperidine

Base Information

• Chemical Name: N-benzyloxycarbonyl-4-methylpiperidine
• CAS No.: 217795-77-2
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.31
• Mol file: 217795-77-2.mol

Synonyms:N-benzyloxycarbonyl-4-methylpiperidine

Chemical Property of N-benzyloxycarbonyl-4-methylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-4-methylpiperidine

There total 2 articles about N-benzyloxycarbonyl-4-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-methylpiperidin (626-58-4) + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyl-4-methylpiperidine (217795-77-2)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; for 1h;

DOI:10.1039/a805800h

Reference yield:

C23H39N3O4S → C15H21NO2 + N-benzyloxycarbonyl-4-methylpiperidine (217795-77-2)

Guidance literature:

In methanol; at 62 ℃; for 2h; Temperature; Inert atmosphere;

DOI:10.1021/jacs.5b05144

Reference yield: 56.0%

N-benzyloxycarbonyl-4-methylpiperidine (217795-77-2) → 4-methyl-2-oxopiperidine-1-carboxylic acid benzyl ester (626232-80-2)

Guidance literature:

With ruthenium(IV) oxide; sodium periodate; In water; ethyl acetate; at 25 ℃; for 2h;

DOI:10.1021/jo034939p

upstream raw materials:

4-methylpiperidin

benzyl chloroformate

Downstream raw materials:

benzyl 4-hydroxy-4-methylpiperidine-1-carboxylate

4-methyl-2-oxopiperidine-1-carboxylic acid benzyl ester

6-(1-ethoxybuta-1,3-dienyl)-4-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

4-methyl-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Refernces

• 1、 Occhiato, Ernesto G.,Prandi, Cristina,Ferrali, Alessandro,Guarna, Antonio,Venturello, Paolo. "New Synthetic Approach to Cyclopenta-Fused Heterocycles Based upon a Mild Nazarov Reaction". . p. 9728 - 9741. Retrieved 2007/10/03.