2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

Base Information

• Chemical Name: 2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone
• CAS No.: 155826-83-8
• Molecular Formula: C₂₂H₁₉N₃O₆S
• Molecular Weight: 453.475
• Mol file: 155826-83-8.mol

Synonyms:2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

Chemical Property of 2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

There total 8 articles about 2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6--2,4-dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine (175791-63-6) → 2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone (155826-83-8)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; for 0.25h; Heating;

DOI:10.1039/p19960000459

Reference yield: 55.0%

4,N-dimethoxy-N-methylbenzamide (52898-49-4) + 2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine (155826-81-6) → 2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone (155826-83-8)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; pentane; 1.) -78 deg C, 0.5 h, 2.) -78 deg C, 2 h;

DOI:10.1039/p19960000459

Reference yield:

2,4-dimethoxy-7H-pyrrolo<2,3-d>pyrimidine (90057-09-3) → 2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone (155826-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaH / tetrahydrofuran / 1.) r.t., 1 h, 2.) r.t., 1 h

2: 55 percent / t-BuLi / tetrahydrofuran; pentane / 1.) -78 deg C, 0.5 h, 2.) -78 deg C, 2 h

With tert.-butyl lithium; sodium hydride; In tetrahydrofuran; pentane;

DOI:10.1039/p19960000459

upstream raw materials:

4,N-dimethoxy-N-methylbenzamide

2,4-Dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine

6--2,4-dimethoxy-7-phenylsulfonylpyrrolo<2,3-d>pyrimidine

4-methoxy-benzaldehyde

Downstream raw materials:

2,4-Dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

6-(4-hydroxybenzoyl)-5-(4-hydroxyphenyl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione

5-Iodo-2,4-dimethoxypyrrolo<2,3-d>pyrimidin-6-yl 4-methoxyphenyl ketone

2,4-Dimethoxy-5-(4-methoxyphenyl)pyrrolo<2,3-d>pyrimidine-6-yl 4-methoxyphenyl ketone

Refernces

• 1、 Sakamoto, Takao,Kondo, Yoshinori,Sato, Shuichiroh,Yamanaka, Hiroshi. "TOTAL SYNTHESIS OF A MARINE ALKALOID, RIGIDIN". . p. 2919 - 2920. Retrieved 2007/10/02.