6 alpha-methyl-17 alpha-hydroxy-11-deoxy-corticosterone-21-acetate

Base Information

• Chemical Name: 6 alpha-methyl-17 alpha-hydroxy-11-deoxy-corticosterone-21-acetate
• CAS No.: 3386-03-6
• Molecular Formula: C24H34 O5
• Molecular Weight: 402.52376
• Mol file: 3386-03-6.mol

Synonyms:Corticosterone,11-deoxy-17-hydroxy-6a-methyl-, 21-acetate (6CI); Pregn-4-ene-3,20-dione, 17,21-dihydroxy-6a-methyl-, 21-acetate (7CI,8CI);21-Acetoxy-17a-hydroxy-6a-methyl-4-pregnene-3,20-dione

Chemical Property of 6 alpha-methyl-17 alpha-hydroxy-11-deoxy-corticosterone-21-acetate

Chemical Property:

• Vapor Pressure: 5.07E-14mmHg at 25°C
• Boiling Point: 542.3°Cat760mmHg
• Flash Point: 180.7°C
• PSA: 80.67000
• Density: 1.19g/cm³
• LogP: 3.62760

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6 alpha-methyl-17 alpha-hydroxy-11-deoxy-corticosterone-21-acetate

There total 9 articles about 6 alpha-methyl-17 alpha-hydroxy-11-deoxy-corticosterone-21-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Medroxyprogesterone (520-85-4) → 21-acetoxy-17-hydroxy-6α-methyl-pregn-4-ene-3,20-dione (3386-03-6)

Guidance literature:

With peroxide containing THF; iodine; calcium oxide; Reagens 4:Methanol; Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton;

DOI:10.1021/ja01523a055

Reference yield:

3β-acetoxy-17α-hydroxy-5-pregnen-20-one (1863-39-4) → 21-acetoxy-17-hydroxy-6α-methyl-pregn-4-ene-3,20-dione (3386-03-6)

Guidance literature:

Multi-step reaction with 7 steps

1: benzene; toluene-4-sulfonic acid

2: peroxybenzoic acid; chloroform

3: benzene; diethyl ether

4: aqueous methanol.H₂SO₄

5: CrO₃; pyridine

6: aqueous HCl

7: iodine; CaO; peroxide containing THF / Reagens 4:Methanol; Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton

With pyridine; chromium(VI) oxide; hydrogenchloride; Perbenzoic acid; diethyl ether; chloroform; peroxide containing THF; sulfuric acid; iodine; toluene-4-sulfonic acid; calcium oxide; benzene;

DOI:10.1021/ja01523a055

Reference yield:

3β,5,17-trihydroxy-6β-methyl-5α-pregnan-20-one (113665-92-2) → 21-acetoxy-17-hydroxy-6α-methyl-pregn-4-ene-3,20-dione (3386-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: CrO₃; pyridine

2: aqueous HCl

3: iodine; CaO; peroxide containing THF / Reagens 4:Methanol; Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton

With pyridine; chromium(VI) oxide; hydrogenchloride; peroxide containing THF; iodine; calcium oxide;

DOI:10.1021/ja01523a055

upstream raw materials:

Medroxyprogesterone

3β-acetoxy-17α-hydroxy-5-pregnen-20-one

3β,5,17-trihydroxy-6β-methyl-5α-pregnan-20-one

5,17-dihydroxy-6β-methyl-5α-pregnane-3,20-dione