5-Methoxytryptamine hydrochloride

Base Information

• Chemical Name: 5-Methoxytryptamine hydrochloride
• CAS No.: 66-83-1
• Molecular Formula: C11H15ClN2O
• Molecular Weight: 226.706
• Hs Code.: 29339900
• European Community (EC) Number: 200-637-6,241-177-6
• UNII: 4265IB6QEK
• DSSTox Substance ID: DTXSID801017272
• Wikidata: Q27258499
• ChEMBL ID: CHEMBL1256138
• Mol file: 66-83-1.mol

Synonyms:5-Methoxytryptamine hydrochloride;66-83-1;Mexamine hydrochloride;O-Methylserotonin hydrochloride;5-Methoxy Tryptamine Hcl;2-(5-methoxy-1H-indol-3-yl)ethanamine hydrochloride;1H-Indole-3-ethanamine, 5-methoxy-, monohydrochloride;3-(2-Aminoethyl)-5-methoxyindole hydrochloride;5-Methoxy-1H-indole-3-ethylamine hydrochloride;5-Methoxytryptamine, HCl;Mexamine HCl;EINECS 200-637-6;MFCD00012684;17107-33-4;UNII-4265IB6QEK;4265IB6QEK;5-Methoxy-1H-indole-3-ethylamine monohydrochloride;EINECS 241-177-6;5-Methoxytryptamine monohydrochloride;5-Methoxy-1H-indole-3-ethylamine HCl;INDOLE, 3-(2-AMINOETHYL)-5-METHOXY-, HYDROCHLORIDE;1,6-Hexanediamine, N,N'-bis(o-chlorobenzyl)-, dihydrochloride;2-(5-Methoxy-1H-indol-3-yl)-ethanamine hydrochloride;2-(5-methoxy-1H-indol-3-yl)ethanamine;hydrochloride;Mexamin;mono-ethylsuccinate;O-Methylserotonin HCl;5-Methoxytryptamine HCl;C11H14N2O.xClH;MEXAMIN HYDROCHLORIDE;C11H14N2O.ClH;1H-Indole-3-ethanamine, 5-methoxy-, hydrochloride;SPECTRUM2300296;SCHEMBL1322980;CHEMBL1256138;DTXSID801017272;C11-H14-N2-O.x-Cl-H;Tox21_500789;CCG-40083;AKOS000291500;3-(2-aminoethyl)-5-methoxyindole HCl;LP00789;O-METHYL SEROTONIN HYDROCHLORIDE;NCGC00094124-01;NCGC00094124-02;NCGC00261474-01;LS-82284;SY005094;TS-03225;O-Methylserotonin hydrochloride, crystalline;5-METHOXYTRYPTAMINE-A,A,B,B-D4 HCL;AM20060707;CS-0030491;EU-0100789;FT-0620578;FT-0770989;5-METHOXYTRYPTAMINE HYDROCHLORIDE [MI];5-methoxy-1H-Indole-3-ethanamine hydrochloride;F13846;M 6628;M-3554;SR-01000076002;SR-01000076002-1;Q27258499;[2-(5-methoxy-1H-indol-3-yl)ethyl]amine hydrochloride;2-(5-methoxy-1H-indol-3-yl)ethan-1-amine hydrochloride;1H-INDOLE-3-ETHANAMINE, 5-METHOXY-, HYDROCHLORIDE (1:1)

Chemical Property of 5-Methoxytryptamine hydrochloride

Chemical Property:

• Appearance/Colour: white to beige crystalline powder
• Vapor Pressure: 5.61E-06mmHg at 25°C
• Melting Point: 246 °C
• Boiling Point: 380 °C at 760 mmHg
• Flash Point: 183.6 °C
• PSA: 51.04000
• Density: 1.171 g/cm3
• LogP: 3.18000
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: Methanol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 226.0872908
• Heavy Atom Count: 15
• Complexity: 186

Purity/Quality:

99%+ ^*data from raw suppliers

5-Methoxytryptamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38-20/21/22
• Safety Statements: 36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)NC=C2CCN.Cl
• Uses: A closely related compound of the neurotransmitter Melatonin (M215000). A metabolite of Melatonin

Technology Process of 5-Methoxytryptamine hydrochloride

There total 4 articles about 5-Methoxytryptamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5-methoxytryptamine-2-carboxylic acid (52648-13-2) → 5-methoxytryptamine hydrochloride (66-83-1)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1021/jm00051a007

Reference yield: 25.0%

hydrogenchloride (7647-01-0,15364-23-5) + 5-methoxy-N-acetyl-tryptamine (73-31-4) → 5-methoxytryptamine hydrochloride (66-83-1)

Guidance literature:

5-methoxy-N-acetyl-tryptamine; With sodium dithionite; sodium hydroxide; In 2-methyl-propan-1-ol; at 100 ℃; for 2h; Inert atmosphere;

hydrogenchloride; In 2-methyl-propan-1-ol; water; Inert atmosphere;

DOI:10.1039/c6cp06580e

Reference yield:

2-(5-methoxyindol-3-yl)ethylamine (608-07-1) → 5-methoxytryptamine hydrochloride (66-83-1)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane;

DOI:10.1107/S2053229621008950

upstream raw materials:

5-methoxytryptamine-2-carboxylic acid

6-methoxy-2,3,4,9-tetrahydro-β-carbolin-1-one

hydrogenchloride

5-methoxy-N-acetyl-tryptamine

Downstream raw materials:

N-Butyryl-5-methoxytryptamine

pinoline

N-Propionyl-5-methoxytryptamine

1-Isopropyl-6-methoxy-2,3,4,9-tetrahydro-1H-β-carboline

Refernces

• 1、 Carrone,Zayat,Slep,Etchenique. "Transient photocyclization in ruthenium(II) polypyridine complexes of indolamines". . p. 2140 - 2147. Retrieved 2017/08/17.