3-(2-bromophenyl)-3-oxo-2-phenylpropanal

Base Information

• Chemical Name: 3-(2-bromophenyl)-3-oxo-2-phenylpropanal
• CAS No.: 1258792-30-1
• Molecular Formula: C₁₅H₁₁BrO₂
• Molecular Weight: 303.155
• Mol file: 1258792-30-1.mol

Synonyms:3-(2-bromophenyl)-3-oxo-2-phenylpropanal

Chemical Property of 3-(2-bromophenyl)-3-oxo-2-phenylpropanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-bromophenyl)-3-oxo-2-phenylpropanal

There total 1 articles about 3-(2-bromophenyl)-3-oxo-2-phenylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-bromo-2-phenylacetophenone (36081-66-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(2-bromophenyl)-3-oxo-2-phenylpropanal (1258792-30-1)

Guidance literature:

With trichlorophosphate; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/co1000103

Reference yield: 97.5%

3-(2-bromophenyl)-3-oxo-2-phenylpropanal (1258792-30-1) + 4-methoxy-aniline (104-94-9) → 1-(4-methoxyphenyl)-3-phenylquinolin-4(1H)-one (1258792-42-5)

Guidance literature:

3-(2-bromophenyl)-3-oxo-2-phenylpropanal; 4-methoxy-aniline; In dimethyl sulfoxide; at 90 - 100 ℃; for 0.5h; Inert atmosphere;

With potassium carbonate; In dimethyl sulfoxide; at 130 ℃; for 8h;

DOI:10.1021/co1000103

Reference yield: 96.0%

3-(2-bromophenyl)-3-oxo-2-phenylpropanal (1258792-30-1) → isoflavone (574-12-9)

Guidance literature:

With 2-Picolinic acid; copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 135 - 140 ℃; for 20h; Inert atmosphere;

DOI:10.1002/hlca.201000400

upstream raw materials:

2'-bromo-2-phenylacetophenone

N,N-dimethyl-formamide

Downstream raw materials:

3-phenyl-1-(pyridin-2-yl)quinolin-4(1H)-one

1-(naphthalen-1-yl)-3-phenylquinolin-4(1H)-one

1-(2,4-dichlorophenyl)-3-phenylquinolin-4(1H)-one

3-phenyl-1-p-tolylquinolin-4(1H)-one

Refernces

• 1、 Li, Qiu-Lian,Liu, Qi-Lun,Ge, Zhi-Yuan,Zhu, Yong-Ming. "A novel synthesis of isoflavones via copper(I)-catalyzed intramolecular cyclization reaction". experimental part. p. 1304 - 1309. Retrieved 2011/09/15.