1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride

Base Information

• Chemical Name: 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride
• CAS No.: 27688-56-8
• Molecular Formula: C₁₅H₁₇NO*ClH
• Molecular Weight: 263.767
• Mol file: 27688-56-8.mol

Synonyms:1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride

Chemical Property of 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride

There total 4 articles about 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl N-(2-(benzoyl)benzyl)-N-methyl-carbamate → 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride (27688-56-8)

Guidance literature:

tert-butyl N-(2-(benzoyl)benzyl)-N-methyl-carbamate; With sodium tetrahydroborate; acetic acid; In methanol; for 2h; Reflux;

With hydrogenchloride; In methanol; water;

Reference yield:

tert-butyl N-benzyl-N-methylcarbamate (81616-14-0) → 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride (27688-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / diethyl ether / 1 h / -78 °C / Inert atmosphere

2: sodium tetrahydroborate; acetic acid / methanol / 2 h / Reflux

With sodium tetrahydroborate; n-butyllithium; acetic acid; In methanol; diethyl ether;

Reference yield:

phenylacetyl chloride (103-80-0) → 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride (27688-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / diethyl ether / 1 h / -78 °C / Inert atmosphere

2: sodium tetrahydroborate; acetic acid / methanol / 2 h / Reflux

With sodium tetrahydroborate; n-butyllithium; acetic acid; In methanol; diethyl ether;

upstream raw materials:

tert-butyl N-benzyl-N-methylcarbamate

phenylacetyl chloride

Downstream raw materials:

nefopam hydrochloride

Refernces