(1S,2R,4R)-(-)-2-tert-butoxy-1-isopropyl-4-methylcyclohexane

Base Information

• Chemical Name: (1S,2R,4R)-(-)-2-tert-butoxy-1-isopropyl-4-methylcyclohexane
• CAS No.: 34350-47-5
• Molecular Formula: C₁₄H₂₈O
• Molecular Weight: 212.376
• Mol file: 34350-47-5.mol

Synonyms:(1S,2R,4R)-(-)-2-tert-butoxy-1-isopropyl-4-methylcyclohexane

Chemical Property of (1S,2R,4R)-(-)-2-tert-butoxy-1-isopropyl-4-methylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,2R,4R)-(-)-2-tert-butoxy-1-isopropyl-4-methylcyclohexane

There total 4 articles about (1S,2R,4R)-(-)-2-tert-butoxy-1-isopropyl-4-methylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(-)-menthol (2216-51-5) + di-tert-butyl dicarbonate (24424-99-5) → (1S,2R,4R)-(-)-2-tert-butoxy-1-isopropyl-4-methylcyclohexane (34350-47-5)

Guidance literature:

With magnesium(II) perchlorate; In dichloromethane; at 40 ℃; for 28h;

DOI:10.1021/ol047704o

Reference yield: 60.0%

acetic acid tert-butyl ester (540-88-5) + (-)-menthol (2216-51-5) → (1S,2R,4R)-(-)-2-tert-butoxy-1-isopropyl-4-methylcyclohexane (34350-47-5)

Guidance literature:

With perchloric acid; at 25 ℃; for 120h;

DOI:10.1055/s-0029-1219360

Reference yield: 27.0%

(-)-menthol (2216-51-5) + tert-butyl alcohol (75-65-0) → (1S,2R,4R)-(-)-2-tert-butoxy-1-isopropyl-4-methylcyclohexane (34350-47-5)

Guidance literature:

With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold (I); at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1002/adsc.201401097

upstream raw materials:

(-)-menthol

isobutene

di-tert-butyl dicarbonate

acetic acid tert-butyl ester

Downstream raw materials:

(-)-menthol

Refernces

• 1、 Shirini,Zolfigol,AbediniM.. "Saccharin sulfonic acid catalyzed N-Boc protection of amines and formation of tertbutyl ethers from alcohols". experimental part. p. 603 - 607. Retrieved 2010/10/21.
• 2、 Bartoli, Giuseppe,Bosco, Marcella,Locatelli, Manuela,Marcantoni, Enrico,Melchiorre, Paolo,Sambri, Letizia. "Unusual and unexpected reactivity of t-butyl dicarbonate (Boc2O) with alcohols in the presence of magnesium perchlorate. A new and general route to t-butyl ethers". . p. 427 - 430. Retrieved 2007/10/03.