N,N-dimethyl-1-(2'-bromobenzoyl)tryptamine

Base Information

• Chemical Name: N,N-dimethyl-1-(2'-bromobenzoyl)tryptamine
• CAS No.: 481661-82-9
• Molecular Formula: C₁₉H₁₉BrN₂O
• Molecular Weight: 371.277
• Mol file: 481661-82-9.mol

Synonyms:N,N-dimethyl-1-(2'-bromobenzoyl)tryptamine

Chemical Property of N,N-dimethyl-1-(2'-bromobenzoyl)tryptamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dimethyl-1-(2'-bromobenzoyl)tryptamine

There total 5 articles about N,N-dimethyl-1-(2'-bromobenzoyl)tryptamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyltryptamine (61-50-7,68677-25-8) + 2-bromobenzoic acid chloride (7154-66-7) → N,N-dimethyl-1-(2'-bromobenzoyl)tryptamine (481661-82-9)

Guidance literature:

With potassium hydride; In tetrahydrofuran; at 10 - 25 ℃; for 2 - 4h;

Reference yield:

indole (120-72-9) → N,N-dimethyl-1-(2'-bromobenzoyl)tryptamine (481661-82-9)

Guidance literature:

Multi-step reaction with 4 steps

1: diethyl ether / Heating

2: NH₃ / dioxane

3: lithium aluminum hydride / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; ammonia; In tetrahydrofuran; 1,4-dioxane; diethyl ether;

DOI:10.1021/ol026729p

Reference yield:

indolyl-3-glyoxylyl chloride (22980-09-2) → N,N-dimethyl-1-(2'-bromobenzoyl)tryptamine (481661-82-9)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₃ / dioxane

2: lithium aluminum hydride / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; ammonia; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/ol026729p

upstream raw materials:

tryptamine

2-bromobenzoic acid chloride

methyl iodide

indole

Refernces

• 1、 Wu, Tom Y. H.,Schulte, Peter G.. "A versatile linkage strategy for solid-phase synthesis of N,N-dimethyltryptamines and β-carbolines". . p. 4033 - 4035. Retrieved 2007/10/03.