N-(t-butoxycarbonyl)-D-2-methylphenylalanine N-methyl-N-methoxyamide

Base Information

• Chemical Name: N-(t-butoxycarbonyl)-D-2-methylphenylalanine N-methyl-N-methoxyamide
• CAS No.: 923563-62-6
• Molecular Formula: C₁₇H₂₆N₂O₄
• Molecular Weight: 322.404
• Mol file: 923563-62-6.mol

Synonyms:N-(t-butoxycarbonyl)-D-2-methylphenylalanine N-methyl-N-methoxyamide

Chemical Property of N-(t-butoxycarbonyl)-D-2-methylphenylalanine N-methyl-N-methoxyamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(t-butoxycarbonyl)-D-2-methylphenylalanine N-methyl-N-methoxyamide

There total 2 articles about N-(t-butoxycarbonyl)-D-2-methylphenylalanine N-methyl-N-methoxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + N-Boc-D-2-methylphenylalanine (80102-29-0) → N-(t-butoxycarbonyl)-D-2-methylphenylalanine N-methyl-N-methoxyamide (923563-62-6)

Guidance literature:

N-Boc-D-2-methylphenylalanine; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; for 2h; pH=> 8; Inert atmosphere;

DOI:10.1016/j.bmc.2011.04.047

Reference yield:

→ N-(t-butoxycarbonyl)-D-2-methylphenylalanine N-methyl-N-methoxyamide (923563-62-6)

Guidance literature:

Reference yield:

N-(t-butoxycarbonyl)-D-2-methylphenylalanine N-methyl-N-methoxyamide (923563-62-6) → N-(t-butoxycarbonyl)-D-2-methylphenylalaninal (1315271-13-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2011.04.047

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

N-Boc-D-2-methylphenylalanine

Downstream raw materials:

N-(t-butoxycarbonyl)-D-2-methylphenylalaninal

(1R,2S,3S,4'S)-[2-hydroxy-1-(2'-methylbenzyl)-4-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-3-methyl-4-oxobutyl]carbamic acid tert-butyl ester

(2S,3S,4R)-4-tert-butoxycarbonylamino-3-hydroxy-2-methyl-5-(2'-methylphenyl)pentanoic acid

(2S,3S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methyl-5-(2'-methylphenyl)pentanoic acid

Refernces

• 1、 -. "PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS". Page/Page column 54-55. . Retrieved 2008/06/13.