Technology Process of (4-Bromomethyl-2-chloro-6-fluoro-phenyl)-(4-chloro-phenyl)-methanone
There total 5 articles about (4-Bromomethyl-2-chloro-6-fluoro-phenyl)-(4-chloro-phenyl)-methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide; dibenzoyl peroxide;
In
benzene;
for 23h;
Heating;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 12.3 g / H2 / 5percent Pt/C / methanol / 1 h / 2068.6 Torr
2: 1.) concd. HCl, aq. NaNO2, 2.) CuCl / 1.) H2O, 0-5 deg C, 10 min, 2.) 60 deg C, 5 min
3: 1.) n-BuLi / 1.) THF, hexane, -40 deg C, 30 min, 2.) THF, -40 deg C, 1 h
4: 53.4 percent / dibenzoyl peroxide, NBS / benzene / 23 h / Heating
With
hydrogenchloride; N-Bromosuccinimide; n-butyllithium; hydrogen; copper(l) chloride; sodium nitrite; dibenzoyl peroxide;
platinum on activated charcoal;
In
methanol; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
2: 12.3 g / H2 / 5percent Pt/C / methanol / 1 h / 2068.6 Torr
3: 1.) concd. HCl, aq. NaNO2, 2.) CuCl / 1.) H2O, 0-5 deg C, 10 min, 2.) 60 deg C, 5 min
4: 1.) n-BuLi / 1.) THF, hexane, -40 deg C, 30 min, 2.) THF, -40 deg C, 1 h
5: 53.4 percent / dibenzoyl peroxide, NBS / benzene / 23 h / Heating
With
hydrogenchloride; N-Bromosuccinimide; n-butyllithium; hydrogen; copper(l) chloride; sodium nitrite; dibenzoyl peroxide;
platinum on activated charcoal;
In
methanol; benzene;