Technology Process of 1-acetyl-N-(2,6-diethylphenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine
There total 1 articles about 1-acetyl-N-(2,6-diethylphenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1: 91.1 percent / H2O / 3 h / Heating
2: 1.) NaNO2, AcOH, 2.) 35percent HNO3 / 1.) H2O, 5 deg C, 1.5 h, 2.) a) 5 deg C, 0.5 h, b) reflux, 1 h
3: Fe, HCl / ethanol; H2O / 0.5 h / Heating
4: 56.3 percent / Br2 / acetic acid; trifluoroacetic acid / 1.) ice-bath temperature, 1.5 h, 2.) ice-bath temperature -> room temperature
5: T2 / 10percent Pd/C / 2 h
With
hydrogenchloride; tritium; water; bromine; nitric acid; iron; acetic acid; sodium nitrite;
palladium on activated charcoal;
In
ethanol; water; acetic acid; trifluoroacetic acid;
DOI:10.1021/jm00128a022