4-Methylaminorex

Base Information

• Chemical Name: 4-Methylaminorex
• CAS No.: 3568-94-3
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.218
• DSSTox Substance ID: DTXSID30860432
• Nikkaji Number: J13.685I
• Wikipedia: 4-Methylaminorex
• Wikidata: Q230007
• Metabolomics Workbench ID: 146105
• Mol file: 3568-94-3.mol

Synonyms:2-Oxazoline,2-amino-4-methyl-5-phenyl- (7CI,8CI); McN 822

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Chemical Property of 4-Methylaminorex

Chemical Property:

• Vapor Pressure: 0.00151mmHg at 25°C
• Boiling Point: 295.6°Cat760mmHg
• Flash Point: 132.6°C
• PSA: 45.11000
• Density: 1.22g/cm³
• LogP: 2.09930
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 176.094963011
• Heavy Atom Count: 13
• Complexity: 209

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C(OC(=N1)N)C2=CC=CC=C2
• Uses: 4-Methylaminorex is a stimulant drug of the 2-amino-5-aryloxazoline class. 4-Methylaminorex has effects similar to Methamphetamine (M258795) but with much longer duration. Studies show that effects of 4-Methylaminorex are stimulant in nature, producing euphoria, an increase in attention, and increased cognition. Controlled Substance.

Technology Process of 4-Methylaminorex

There total 5 articles about 4-Methylaminorex which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1-propenylbenzene (873-66-5) + urea (57-13-6) → 5-methyl-4-phenyl-4,5-dihydrooxazol-2-amine (63204-72-8,63204-73-9,70250-62-3,90917-82-1) + 4-methylaminorex (3568-94-3)

Guidance literature:

With Selectfluor; lithium iodide; In dichloromethane; at 80 ℃; for 16h; diastereoselective reaction;

DOI:10.1002/anie.201904662

Reference yield:

bromocyane (506-68-3) + norephedrine (54680-46-5,58550-13-3,757124-50-8) → 4r-methyl-5t-phenyl-4,5-dihydro-oxazol-2-ylamine (2077-59-0,3568-94-3,10189-63-6,27780-30-9,27780-31-0,29493-77-4,42510-77-0,75493-87-7,127253-86-5)

Guidance literature:

With sodium acetate; In methanol;

DOI:10.1021/jm00339a011

Reference yield:

bromocyane (506-68-3) + u-2-amino-1-phenylpropan-1-ol (14838-15-4,58550-13-3,757124-50-8) → 4r-methyl-5c-phenyl-4,5-dihydro-oxazol-2-ylamine (2077-59-0,3568-94-3,10189-63-6,27780-30-9,27780-31-0,29493-77-4,42510-77-0,75493-87-7,127253-86-5)

Guidance literature:

With sodium acetate; In methanol;

DOI:10.1021/jm00339a011

upstream raw materials:

1-propenylbenzene

urea

u-2-amino-1-phenylpropan-1-ol

cyanogen chloride

Downstream raw materials:

N-(1-Methyl-2-phenylethyl)harnstoff

3,4r-dimethyl-5c-phenyl-oxazolidin-2-ylideneamine

Refernces

• 1、 Wollweber,Hiltmann. "Stereospecific cyclization of -omega-disubstituted aminoethanols. 1. 1-aryl-3-imino-3H-oxazolo-(3,4-a) perhydro-pyridine and related compounds". . p. 284 - 299. Retrieved 2007/10/04.