4-MERCAPTOPYRAZOLO[3,4D]PYRIMIDINE

Base Information

• Chemical Name: 4-MERCAPTOPYRAZOLO[3,4D]PYRIMIDINE
• CAS No.: 5334-23-6
• Molecular Formula: C5H4 N4 S
• Molecular Weight: 152.18
• Hs Code.: 2933990090
• Mol file: 5334-23-6.mol

Synonyms:1H-Pyrazolo[3,4-d]pyrimidine-4(5H)-thione(7CI); 1H-Pyrazolo[3,4-d]pyrimidine-4-thiol; 4-Mercapto-1H-pyrazolo[3,4-d]pyrimidine;4-Mercaptopyrazolo[3,4-d]pyrimidine; 5H-Pyrazolo[3,4-d]pyrimidine-4-thione;8-Aza-7-deaza-6-thiopurine; Allopurinol, thio-; MPP; MPP (pharmaceutical); NSC1392; Thiopurinol; Tisopurine

Chemical Property of 4-MERCAPTOPYRAZOLO[3,4D]PYRIMIDINE

Chemical Property:

• Vapor Pressure: 7.69E-06mmHg at 25°C
• Melting Point: 300oC
• Refractive Index: 1.5605 (estimate)
• Boiling Point: 386.8°C at 760 mmHg
• PKA: 8.44±0.20(Predicted)
• Flash Point: 187.7°C
• PSA: 93.26000
• Density: 1.463 (estimate)
• LogP: 0.64160

Purity/Quality:

99% ^*data from raw suppliers

1H-Pyrazolo[3,4-d]pyrimidine-4-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-MERCAPTOPYRAZOLO[3,4D]PYRIMIDINE

There total 4 articles about 4-MERCAPTOPYRAZOLO[3,4D]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Allopurinol (315-30-0) → 4-Mercapto-1H-pyrazolo<3,4-d>pyrimidine (5334-23-6)

Guidance literature:

With tetraphosphorus decasulfide; In pyridine; Heating;

DOI:10.1081/NCN-100107191

Reference yield:

→ tisopurine (5334-23-6)

Guidance literature:

DOI:10.1021/ja01462a050

Reference yield:

4-chloro-1H-pyrazolo[3,4-d]pyrimidine (5399-92-8) → 4-Mercapto-1H-pyrazolo<3,4-d>pyrimidine (5334-23-6)

Guidance literature:

With ethanol; thiourea;

DOI:10.1021/ja01585a023

upstream raw materials:

Allopurinol

4-chloro-1H-pyrazolo[3,4-d]pyrimidine

Downstream raw materials:

4-methylthio-1H-pyrazolo[3,4-d]pyrimidine

4-mercapto-1-β-D-ribofuranosyl-1H-pyrazolo<3,4-d>pyrimidine

4-benzylsulfanyl-1⁽²⁾H-pyrazolo[3,4-d]pyrimidine

4-(2-chloro-benzylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine

Refernces

• 1、 Moukha-Chafiq,Taha,Lazrek,Pannecouque,Witvrouw,De Clercq,Barascut,Imbach. "Synthesis and biological activity of 4-substituted 1-[1-(2-hydroxyethoxy)-methyl-1,2,3-triazol-(4 & 5)-Ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines". . p. 1797 - 1810. Retrieved 2007/10/03.