acetophenone enol trifluoroacetate

Base Information

• Chemical Name: acetophenone enol trifluoroacetate
• CAS No.: 3018-24-4
• Molecular Formula: C₁₀H₇F₃O₂
• Molecular Weight: 216.16
• Mol file: 3018-24-4.mol

Synonyms:acetophenone enol trifluoroacetate

Chemical Property of acetophenone enol trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of acetophenone enol trifluoroacetate

There total 3 articles about acetophenone enol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

acetophenone (98-86-2) + trifluoroacetyl triflate (68602-57-3) → acetophenone enol trifluoroacetate (3018-24-4)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; In tetrachloromethane; at 25 ℃; for 6h;

DOI:10.1021/jo00228a002

Reference yield:

phenylacetylene (536-74-3) + trifluoroacetic acid (76-05-1) → acetophenone enol trifluoroacetate (3018-24-4) + C10H7F3O2 (1391935-49-1) + (Z)-β-Styryl trifluoroacetate

Guidance literature:

With C₅₄H₆₂N₁₀Ru⁽²⁺⁾*2F₆P^(1-); In dichloromethane; toluene; at 100 ℃; for 24h; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/om300469n

Reference yield:

trifluoroacetyl bromide (354-31-4) + (2-oxo-2-phenylethyl)mercury chloride (28531-58-0) → acetophenone enol trifluoroacetate (3018-24-4)

Guidance literature:

In nitrobenzene;

upstream raw materials:

trifluoroacetyl bromide

(2-oxo-2-phenylethyl)mercury chloride

acetophenone

trifluoroacetyl triflate

Downstream raw materials:

(t-C₄H₉)2SbCH₂COC₆H₅

trifluoroacetic acid-methyl ester

Refernces

• 1、 Forbus, T. R.,Taylor, S. L.,Martin, J. C.. "Reactions of the Readily Accessible Electrophile, Trifluoroacetyl Triflate: A Very Reactive Agent for Trifluoroacetylations at Oxygen, Nitrogen, Carbon, or Halogen Centers". . p. 4156 - 4159. Retrieved 2007/10/02.