8-phenylguanosine

Base Information

• Chemical Name: 8-phenylguanosine
• CAS No.: 79953-03-0
• Molecular Formula: C16H17 N5 O5
• Molecular Weight: 359.341
• Mol file: 79953-03-0.mol

Synonyms:

Chemical Property of 8-phenylguanosine

Chemical Property:

• Vapor Pressure: 6.21E-25mmHg at 25°C
• Boiling Point: 769.9°Cat760mmHg
• Flash Point: 419.4°C
• Density: 1.85g/cm³

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-phenylguanosine

There total 5 articles about 8-phenylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

8-bromoguanosine (4016-63-1) + phenylboronic acid (98-80-6) → 8-phenylguanosine (79953-03-0)

Guidance literature:

With 3,3′,3″-phosphinetriyltribenzenesulfonate; palladium diacetate; sodium carbonate; In water; acetonitrile; at 83 ℃; for 20h;

DOI:10.1021/acs.joc.1c00502

Reference yield: 80.0%

8-bromoguanosine (4016-63-1) + phenylboronic acid (98-80-6) → 8-phenylguanosine (79953-03-0)

Guidance literature:

With triphenylphosphine trisulfonic acid; potassium carbonate; palladium (II) nitrate; In water; at 80 ℃; for 1h;

DOI:10.1039/b614477b

Reference yield: 21.0%

benzenediazonium tetrafluoroborate (369-57-3) + G (118-00-3) → 8-phenylguanosine (79953-03-0)

Guidance literature:

In sodium hydroxide; at 25 ℃; for 24h; pH 10-11;

DOI:10.1021/jo00342a014

upstream raw materials:

benzenediazonium tetrafluoroborate

G

8-bromoguanosine

phenylboronic acid

Downstream raw materials:

8-phenylguanine

Refernces

• 1、 Storr, Thomas E.,Baumann, Christoph G.,Thatcher, Robert J.,De Ornellas, Sara,Whitwood, Adrian C.,Fairlamb, Ian J. S.. "Pd(0)/Cu(I)-mediated direct arylation of 2′-deoxyadenosines: Mechanistic role of Cu(I) and reactivity comparisons with related purine nucleosides". supporting information; experimental part. p. 5810 - 5821. Retrieved 2009/12/26.
• 2、 Collier, Alice,Wagner, Gerd. "A facile two-step synthesis of 8-arylated guanosine mono- and triphosphates (8-aryl GXPs)". . p. 4526 - 4532. Retrieved 2008/09/19.