Benzaldehyde tosylhydrazone

Base Information

• Chemical Name: Benzaldehyde tosylhydrazone
• CAS No.: 1666-17-7
• Molecular Formula: C14H14 N2 O2 S
• Molecular Weight: 274.343
• Hs Code.: 2935009090
• European Community (EC) Number: 627-257-7
• NSC Number: 126924,126449,234743
• ChEMBL ID: CHEMBL471445
• Mol file: 1666-17-7.mol

Synonyms:Benzaldehyde tosylhydrazone;1666-17-7;N'-benzylidene-4-methylbenzenesulfonohydrazide;N-[(E)-benzylideneamino]-4-methylbenzenesulfonamide;17227-34-8;Benzaldehyde p-Toluenesulfonylhydrazone;(E)-N'-benzylidene-4-methylbenzenesulfonohydrazide;NSC126924;SCHEMBL714847;SCHEMBL714848;CHEMBL471445;Benzaldehyde tosylhydrazone, 98%;Benzenesulfonic acid, 4-methyl-, 2-(phenylmethylene)hydrazide;BAA66617;NSC126449;NSC234743;AKOS001572740;NSC-126449;NSC-126924;NSC-234743;AS-71154;(E)-N'-Benzylidene-p-toluenesulfonohydrazide;CS-0153023;SR-01000106142;J-010302;SR-01000106142-1;N-[(E)-benzylideneamino]-4-methyl-benzenesulfonamide;4-methyl-N'-(phenylmethylidene)benzene-1-sulfonohydrazide;4-methyl-n'-[(1e)-phenylmethylene]benzenesulfonohydrazide

Chemical Property of Benzaldehyde tosylhydrazone

Chemical Property:

• Vapor Pressure: 1.17E-07mmHg at 25°C
• Melting Point: 130 °C
• Boiling Point: 431.8°C at 760 mmHg
• PKA: 9.71±0.40(Predicted)
• Flash Point: 214.9°C
• PSA: 66.91000
• Density: 1.19g/cm³
• LogP: 3.77910
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 274.07759887
• Heavy Atom Count: 19
• Complexity: 386

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzaldehyde p-Toluenesulfonylhydrazone >98.0%(HPLC)(T) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NN=CC2=CC=CC=C2
• Isomeric SMILES: CC1=CC=C(C=C1)S(=O)(=O)N/N=C/C2=CC=CC=C2

Technology Process of Benzaldehyde tosylhydrazone

There total 16 articles about Benzaldehyde tosylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzaldehyde (100-52-7) + toluene-4-sulfonic acid hydrazide (1576-35-8) → (E)-N′-benzylidene-4-methylbenzenesulfonohydrazide (1666-17-7)

Guidance literature:

With acetic acid; In methanol; at 60 ℃; for 3h;

DOI:10.1016/j.tetlet.2016.12.085

Reference yield: 98.0%

benzaldehyde (100-52-7) + toluene-4-sulfonic acid hydrazide (1576-35-8) → benzaldehyde p-toluenesulfonylhydrazone (1666-17-7)

Guidance literature:

In ethanol; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b04459

Reference yield: 96.0%

benzonitrile (100-47-0) + toluene-4-sulfonic acid hydrazide (1576-35-8) → benzaldehyde p-toluenesulfonylhydrazone (1666-17-7)

Guidance literature:

With pyridine; sodium hypophosphite; nickel; In water; acetic acid; at 20 ℃;

DOI:10.1016/S0040-4039(01)00223-4

upstream raw materials:

benzaldehyde

toluene-4-sulfonic acid hydrazide

benzonitrile

p-toluenesulfonyl chloride

Downstream raw materials:

N-benzyl-N'-benzylidene-4-methylbenzenesulfonohydrazide

C₁₆H₂₁N₂O₅PS

α-morpholino-α,α'-diphenylazine

1-(diethoxyphosphoryl)-2-(phenylmethylidene)hydrazine

Refernces

• 1、 Wang, Dong,De Wit, Martin J. M.,Szabó, Kálmán J.. "Synthesis of Densely Substituted Conjugated Dienes by Transition-Metal-Free Reductive Coupling of Allenylboronic Acids and Tosylhydrazones". . p. 8786 - 8792. Retrieved 2018.
• 2、 Qiu, Shanguang,Chen, Yuxue,Song, Xinming,Liu, Li,Liu, Xi,Wu, Luyong. "Potassium tert -Butoxide Promoted Synthesis of 4,5-Diaryl-2 H -1,2,3-triazoles from Tosylhydrazones and Nitriles". supporting information. p. 86 - 90. Retrieved 2020/11/02.
• 3、 Bian, Xue-Wei,Zhang, Ling,Shoberu, Adedamola,Zou, Jian-Ping. "Mn(III)-mediated phosphinoylation of aldehyde hydrazones: Direct “one-pot” synthesis of α-iminophosphine oxides from aldehydes". supporting information. . Retrieved 2021/04/02.