Technology Process of Δ2-4(R)-avermectin B1a
There total 1 articles about Δ2-4(R)-avermectin B1a which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole;
In
benzene;
at 80 - 85 ℃;
for 3h;
DOI:10.1021/ja00257a026
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / triethylamine, 4-DMAP / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) room temperature, 24 h
2: 1.) diisopropylamine, n-butyllithium, trimethylsilyl chloride, 2.) 2N HCl / 1.) THF, -78 deg C, 2.5 min, 2.) THF, H2O, room temperature, 5 h
3: 34 percent Chromat. / NaOMe / methanol / 7.5 h / 25 °C
With
hydrogenchloride; dmap; n-butyllithium; chloro-trimethyl-silane; sodium methylate; triethylamine; diisopropylamine;
In
methanol; dichloromethane;
DOI:10.1021/ja00257a026
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 99 percent / triethylamine, 4-DMAP / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) room temperature, 24 h
2: 1.) diisopropylamine, n-butyllithium, trimethylsilyl chloride, 2.) 2N HCl / 1.) THF, -78 deg C, 2.5 min, 2.) THF, H2O, room temperature, 5 h
With
hydrogenchloride; dmap; n-butyllithium; chloro-trimethyl-silane; triethylamine; diisopropylamine;
In
dichloromethane;
DOI:10.1021/ja00257a026
