Isopropamide Iodide

Base Information

• Chemical Name: Isopropamide Iodide
• CAS No.: 71-81-8
• Molecular Formula: C23H33 N2 O . I
• Molecular Weight: 480.432
• Hs Code.: 2924299090
• European Community (EC) Number: 200-766-8
• NSC Number: 757066
• UNII: E0KNA372SZ
• DSSTox Substance ID: DTXSID30221221
• Wikidata: Q27276712
• NCI Thesaurus Code: C65982
• ChEMBL ID: CHEMBL1200347
• Mol file: 71-81-8.mol

Synonyms:Bispan;isopropamide iodide

Chemical Property of Isopropamide Iodide

Chemical Property:

• Melting Point: 199℃ (Decomposition)
• PSA: 43.09000
• Density: 1.2711 (estimate)
• LogP: 1.81580
• Water Solubility.: Practically insoluble in water
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 8
• Exact Mass: 480.16376
• Heavy Atom Count: 27
• Complexity: 419

Purity/Quality:

98%,99%, ^*data from raw suppliers

Isopropamide iodide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)[N+](C)(CCC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)N)C(C)C.[I-]
• Uses: Isopropamide Iodide acts as an anticholinergic compound with inhibitory activity. Also acts as a muscarinic receptor antagonist which can be applied to treatment of diseases affecting cognition including Alzheimer’s disease.
• Therapeutic Function: Spasmolytic
• Clinical Use: ISOPROPAMIDE IODIDE is used as adjunctive therapy in the treatment of pepticulcer and other conditions of the GI tract associated withhypermotility and hyperacidity. It has the usual side effectsof anticholinergics (dryness of mouth, mydriasis, difficulturination) and is contraindicated in glaucoma, prostatic hypertrophy,etc.

Technology Process of Isopropamide Iodide

There total 2 articles about Isopropamide Iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-diisopropylamino-2,2-diphenyl-butyric acid amide (39666-27-8) + methyl iodide (74-88-4) → isopropamide iodide (71-81-8)

Guidance literature:

With ethanol;

Reference yield:

4-diisopropylamino-2,2-diphenyl-butyronitrile (77-11-2) → isopropamide iodide (71-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: isopropyl alcohol

With sulfuric acid; isopropyl alcohol;

upstream raw materials:

4-diisopropylamino-2,2-diphenyl-butyric acid amide

methyl iodide

4-diisopropylamino-2,2-diphenyl-butyronitrile