N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide

Base Information

• Chemical Name: N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide
• CAS No.: 186755-46-4
• Molecular Formula: C₂₅H₃₂N₂O₂
• Molecular Weight: 392.541
• Mol file: 186755-46-4.mol

Synonyms:N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide

Chemical Property of N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide

There total 1 articles about N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-amino-1-benzylpiperidine (50541-93-0) + 2-cyclopentyl-2-hydroxy-2-phenylacetic acid (427-49-6) → N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide (186755-46-4)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In chloroform; at 20 ℃; for 14h;

DOI:10.1021/jm0003135

Reference yield: 74.0%

N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide (186755-46-4) → N-(piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide (185030-18-6)

Guidance literature:

With hydrogen; 20percent Pd(OH)2; In ethanol; for 8h; under 760.051 Torr;

DOI:10.1021/jm0003135

Reference yield:

N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide (186755-46-4) → 2-cyclopentyl-2-hydroxy-N-[1-(3-methyl-benzyl)-piperidin-4-yl]-2-phenyl-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / H₂ / 20percent Pd(OH)2 / ethanol / 8 h / 760.05 Torr

2: 73 percent / acetic acid; sodium triacetoxyborohydride / tetrahydrofuran / 18 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; 20percent Pd(OH)2; In tetrahydrofuran; ethanol;

DOI:10.1021/jm0003135

upstream raw materials:

4-amino-1-benzylpiperidine

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Downstream raw materials:

N-(piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide

Refernces