Balofloxacin

Base Information

• Chemical Name: Balofloxacin
• CAS No.: 127294-70-6
• Deprecated CAS: 165619-85-2
• Molecular Formula: C20 H24FN3O4
• Molecular Weight: 389.42
• Hs Code.: 2933990090
• UNII: Q022B63JPM
• DSSTox Substance ID: DTXSID5046695
• Nikkaji Number: J501.164G
• Wikipedia: Balofloxacin
• Wikidata: Q3633495
• NCI Thesaurus Code: C72631
• Metabolomics Workbench ID: 144349
• ChEMBL ID: CHEMBL1210954
• Mol file: 127294-70-6.mol

Synonyms:1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylaminopiperidine-1-yl)-4-oxoquinoline-3-carboxylic acid;balofloxacin;Q 35;Q-35

Chemical Property of Balofloxacin

Chemical Property:

• Appearance/Colour: crystalline solid
• Vapor Pressure: 1.19E-15mmHg at 25°C
• Melting Point: 137 °C
• Refractive Index: 1.639
• Boiling Point: 608.3 °C at 760 mmHg
• PKA: 6.44±0.50(Predicted)
• Flash Point: 321.7 °C
• PSA: 60.69000
• Density: 1.4 g/cm³
• LogP: 3.98360
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 389.17508442
• Heavy Atom Count: 28
• Complexity: 668

Purity/Quality:

99% ^*data from raw suppliers

Balofloxacin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
• Description: Balofloxacin, a novel orally-active fluoroquinolone antibiotic, was introduced in South Korea for the treatment of urinary tract infections (UTI). It can be synthetized by reaction of 3-(methylamino)piperidine with the classical 4-quinolone-3-carboxylic acid template. In vitro antibacterial activity of balofloxacin against gram-positive bacteria (Staphylococcus aureus including methicillin-resistant S. aureus, Staphylococcus epidermis, Streptococcus pneumonia, Streptococcus pyrogenes) was almost equal to that of sparfloxacin or tosufloxacin, in contrast its activity against gram-negative bacteria was 2 times or more lower. In clinical trials, balofloxacin was well tolerated and showed comparable efficacy to ofloxacin in patients with UTls. After oral administration, balofloxacin was well absorbed, and was primarily eliminated unchanged in the urine with an elimination half-life of approximately 8 h. In animal studies, balofloxacin did not exhibit any phototoxicity.
• Uses: Fluorinated quinolone antibacterial. Balofloxacin is quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.
• Therapeutic Function: Antibacterial