1α,3β-bis(diazoacetyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane

Base Information

• Chemical Name: 1α,3β-bis(diazoacetyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane
• CAS No.: 75456-17-6
• Molecular Formula: C₂₂H₂₀N₄O₄
• Molecular Weight: 404.425
• Mol file: 75456-17-6.mol

Synonyms:1α,3β-bis(diazoacetyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane

Chemical Property of 1α,3β-bis(diazoacetyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1α,3β-bis(diazoacetyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane

There total 4 articles about 1α,3β-bis(diazoacetyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + p,p'-Dimethoxy-α-truxillsaeure-dichlorid (40493-49-0) → 1α,3β-bis(diazoacetyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane (75456-17-6)

Guidance literature:

In diethyl ether; benzene;

DOI:10.1021/jm00186a023

Reference yield:

p-Coumaric Acid (7400-08-0,50940-26-6) → 1α,3β-bis(diazoacetyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane (75456-17-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / H₂O / 7 h / Irradiation

2: 95 percent / 2M NaOH / 4 h / 80 °C

3: 92 percent / SOCl₂, pyridine / benzene / 1 h / Heating

4: 87 percent / benzene; diethyl ether

With pyridine; sodium hydroxide; thionyl chloride; In diethyl ether; water; benzene;

DOI:10.1021/jm00186a023

Reference yield:

2α, 4β-bis(4-hydroxyphenyl)cyclobutane-1α,3β-dicarboxylic acid (490-18-6) → 1α,3β-bis(diazoacetyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane (75456-17-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / 2M NaOH / 4 h / 80 °C

2: 92 percent / SOCl₂, pyridine / benzene / 1 h / Heating

3: 87 percent / benzene; diethyl ether

With pyridine; sodium hydroxide; thionyl chloride; In diethyl ether; benzene;

DOI:10.1021/jm00186a023

upstream raw materials:

diazomethane

p,p'-Dimethoxy-α-truxillsaeure-dichlorid

p-Coumaric Acid

2α, 4β-bis(4-hydroxyphenyl)cyclobutane-1α,3β-dicarboxylic acid

Downstream raw materials:

[3-Carboxymethyl-2,4-bis-(4-methoxy-phenyl)-cyclobutyl]-acetic acid

1α,3β-bis(carbomethoxymethyl)-2α,4β-bis(4-methoxyphenyl)cyclobutane

Refernces