4'-Phenyl-o-acetotoluide

Base Information

• Chemical Name: 4'-Phenyl-o-acetotoluide
• CAS No.: 63040-30-2
• Molecular Formula: C15H15NO
• Molecular Weight: 225.31
• Hs Code.: 2924299090
• Mol file: 63040-30-2.mol

Synonyms:3-Methyl-4-acetylaminobiphenyl;4'-Phenyl-o-acetotoluide;N-(3-methylbiphenyl-4-yl)acetamide;4-Acetamino-3-methyl-diphenyl;4-Acetamino-3-methyl-biphenyl;o-ACETOTOLUIDIDE,4'-PHENYL;

Chemical Property of 4'-Phenyl-o-acetotoluide

Chemical Property:

• Vapor Pressure: 1.5E-06mmHg at 25°C
• Refractive Index: 1.5200 (estimate)
• Boiling Point: 398.2°C at 760 mmHg
• Flash Point: 240.2°C
• PSA: 32.59000
• Density: 1.103g/cm³
• LogP: 4.26990

Purity/Quality:

99% ^*data from raw suppliers

4'-PHENYL-ORTHO-ACETOTOLUIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-Phenyl-o-acetotoluide

There total 7 articles about 4'-Phenyl-o-acetotoluide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4'-bromo-2'-methylacetanilide (24106-05-6) + phenylboronic acid (98-80-6) → N-(3-methyl-biphenyl-4-yl)-acetamide (63040-30-2)

Guidance literature:

With {2,6-bis[(di-1-piperidinylphosphino)amino]phenyl}palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; butan-1-ol; at 100 ℃; for 5h;

DOI:10.1002/adsc.200900848

Reference yield: 95.0%

4'-bromo-2'-methylacetanilide (24106-05-6) + diphenylzinc (1078-58-6) → N-(3-methyl-biphenyl-4-yl)-acetamide (63040-30-2)

Guidance literature:

With dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium(II); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 100 ℃; for 0.0833333h; In air;

DOI:10.1002/chem.201001201

Reference yield: 89.0%

4'-bromo-2'-methylacetanilide (24106-05-6) + potassium phenyltrifluoborate → N-(3-methyl-biphenyl-4-yl)-acetamide (63040-30-2)

Guidance literature:

With {2,6-bis[(di-1-piperidinylphosphino)amino]phenyl}palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; butan-1-ol; at 100 ℃; for 8h;

DOI:10.1002/adsc.200900848

upstream raw materials:

N-chloro-2'-methylacetanilide

3-methylbiphenyl-4-amine

acetic anhydride

benzene

Downstream raw materials:

3-methylbiphenyl-4-amine

2-Amino-5-phenyl-benzoic acid

1-bromo-2-methyl-4-phenylbenzene

Refernces

• 1、 Bolliger, Jeanne L.,Frech, Christian M.. "Dichloro-bis(aminophosphine) complexes of palladium: Highly convenient, reliable and extremely active suzuki-miyaura catalysts with excellent functional group tolerance". supporting information; experimental part. p. 4075 - 4081. Retrieved 2010/08/05.
• 2、 Mikami, Masafumi,Shinkai, Seiji. "Synthesis of Sugar-containing Polymers by Self-condensation with Diboronic Acid". . p. 153 - 154. Retrieved 2007/10/02.