CID 16219411

Base Information

• Chemical Name: CID 16219411
• CAS No.: 125-04-2
• Molecular Formula: C25H33NaO8
• Molecular Weight: 502.59
• European Community (EC) Number: 204-725-5
• Wikipedia: Hydrocortisone_sodium_succinate
• Mol file: 125-04-2.mol

Synonyms:Hydrocortisone 21-hemisuccinate sodium salt;125-04-2;Hydrocortisone hemisuccinate sodium salt;SCHEMBL1320103;AKOS024386295;sodium;4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid

Chemical Property of CID 16219411

Chemical Property:

• Vapor Pressure: 9.36E-22mmHg at 25°C
• Melting Point: 169.0-171.2°
• Boiling Point: 685.5 °C at 760 mmHg
• Flash Point: 231.1 °C
• PSA: 141.03000
• LogP: 0.86260
• Storage Temp.: −20°C
• Solubility.: H2O: 50 mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 485.21513732
• Heavy Atom Count: 34
• Complexity: 908

Purity/Quality:

83.1%,83.3%, ^*data from raw suppliers

HydrocortisoneHemisuccinateSodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)O)O)C)O.[Na]
• Isomeric SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CCC(=O)O)O)C)O.[Na]
• Recent EU Clinical Trials: Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (COVID-19)
• Uses: Hydrocortisone Hemisuccinate Sodium is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone Hemisuccinate Sodium is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc. Hydrocortisone sodium succinate is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone sodium succinate is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc. Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 μM for IL-6). It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.
• Clinical Use: #N/A
• Drug interactions: Potentially hazardous interactions with other drugs Aldesleukin: avoid concomitant use. Antibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycin; concentration of isoniazid possibly reduced. Anticoagulants: efficacy of coumarins and phenindione may be altered. Antiepileptics: metabolism accelerated by carbamazepine, fosphenytoin, phenobarbital, phenytoin and primidone. Antifungals: increased risk of hypokalaemia with amphotericin - avoid; metabolism possibly inhibited by itraconazole and ketoconazole. Antivirals: concentration possibly increased by ritonavir. Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroids. Cobicistat: concentration of hydrocortisone possibly increased - increased risk of adrenal suppression. Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diuretics. Vaccines: high dose corticosteroids can impair immune response to vaccines - avoid concomitant use with live vaccines.