Technology Process of 2',3'-dideoxy-O6-(2,4,6-triisopropylbenzenesulfonyl)inosine
There total 5 articles about 2',3'-dideoxy-O6-(2,4,6-triisopropylbenzenesulfonyl)inosine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2-acetoxyisobutyryl bromide / acetonitrile / 10 h / 20 °C
1.2: pyridine / 0.5 h / 20 °C
1.3: 146 mg / Zn-Cu; glacial acetic acid / tetrahydrofuran / 12 h / 20 °C
2.1: 72 percent / H2; H2O / Pd/C / methanol / 2 h
3.1: 12 percent / 4-DMAP; Et3N / CH2Cl2 / 4 h / 20 °C
4.1: 54 percent / NH3 / methanol / 5 h / 0 °C
With
dmap; acetoxyisobutyryl bromide; ammonia; water; hydrogen; triethylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(01)00800-6
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 72 percent / H2; H2O / Pd/C / methanol / 2 h
2: 12 percent / 4-DMAP; Et3N / CH2Cl2 / 4 h / 20 °C
3: 54 percent / NH3 / methanol / 5 h / 0 °C
With
dmap; ammonia; water; hydrogen; triethylamine;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)00800-6