Tetrahydro-2-(4-methylphenoxy)-2H-pyran

Base Information

• Chemical Name: Tetrahydro-2-(4-methylphenoxy)-2H-pyran
• CAS No.: 13481-09-9
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Hs Code.: 2932999099
• European Community (EC) Number: 236-784-8
• UNII: 5TG35V9PBQ
• DSSTox Substance ID: DTXSID7051686
• Nikkaji Number: J241.133D
• Wikidata: Q27262840
• Mol file: 13481-09-9.mol

Synonyms:13481-09-9;2-(4-methylphenoxy)oxane;2-(p-Tolyloxy)tetrahydro-2H-pyran;Tetrahydro-2-(4-methylphenoxy)-2H-pyran;2H-Pyran, tetrahydro-2-(4-methylphenoxy)-;Tetrahydro-2-(p-tolyloxy)-2H-pyran;EINECS 236-784-8;UNII-5TG35V9PBQ;5TG35V9PBQ;2-(4-methylphenoxy)tetrahydro-2H-pyran;SCHEMBL818344;4-METHYLPHENYL THP ETHER;DTXSID7051686;AKOS022173166;Tetrahydro-2-(p-tolyloxy)-2H-pyrane;2-(4-methyl-phenoxy)-tetrahydro-pyran;P-CRESYL 2-TETRAHYDROPYRANYL ETHER;2H-Pyran,tetrahydro-2-(4-methylphenoxy)-;4-METHYLPHENYL TETRAHYDROPYRANYL ETHER;4-METHYLPHENYL 2-TETRAHYDROPYRANYL ETHER;tetrahydro - 2 - (p - tolyloxy) - 2H - pyran;Q27262840;TETRAHYDRO-2-((4-METHYLPHENYL)OXY)-2H-PYRAN

Chemical Property of Tetrahydro-2-(4-methylphenoxy)-2H-pyran

Chemical Property:

• Vapor Pressure: 0.00255mmHg at 25°C
• Refractive Index: 1.52
• Boiling Point: 296.3 °C at 760 mmHg
• Flash Point: 117.6 °C
• PSA: 18.46000
• Density: 1.049 g/cm³
• LogP: 2.90040
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 192.115029749
• Heavy Atom Count: 14
• Complexity: 162

Purity/Quality:

99% ^*data from raw suppliers

2-(p-Tolyloxy)tetrahydro-2H-pyran 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)OC2CCCCO2

Technology Process of Tetrahydro-2-(4-methylphenoxy)-2H-pyran

There total 6 articles about Tetrahydro-2-(4-methylphenoxy)-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-dihydro-2H-pyran (110-87-2) + p-cresol (106-44-5) → 2-(4-methylphenoxy)tetrahydro-2H-pyran (13481-09-9)

Guidance literature:

With zirconium(IV) chloride; In dichloromethane; for 0.8h;

DOI:10.1080/00397910008087225

Reference yield: 80.0%

tetrahydro-2H-2-pyranol (694-54-2) + p-cresol (106-44-5) → 2-(4-methylphenoxy)tetrahydro-2H-pyran (13481-09-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1055/s-2005-918916

Reference yield: 80.0%

3,4-dihydro-2H-pyran (110-87-2) + toluene (108-88-3,15644-74-3,16713-13-6) → 2-(4-methylphenoxy)tetrahydro-2H-pyran (13481-09-9)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; at 20 ℃; for 2h;

DOI:10.1002/ejoc.200300295

upstream raw materials:

3,4-dihydro-2H-pyran

p-cresol

toluene

tetrahydro-2H-2-pyranol

Downstream raw materials:

p-cresol

4-methyl-2-(tetrahydro-2H-pyran-2-yl)phenol

(2-hydroxy-5-methylphenyl)boronic acid

methyl 4-methyl-2-(tetrahydro-2H-pyran-2-yl)phenyl ether

Refernces

• 1、 Sarkar, Anjana,Yemul, Omprakash S.,Bandgar,Gaikwad,Wadgaonkar, Prakash P.. "Sulfated zirconia as an efficient catalyst for tetrahydro pyranylation and acetalization". . p. 613 - 617. Retrieved 1996.
• 2、 Wang, Min,Song, Zhi-Guo,Jiang, Heng,Gong, Hong. "Copper p-toluenesulfonate/acetic acid: A recyclable synergistic catalytic system for the tetrahydropyranylation of alcohols and phenols". . p. 601 - 604. Retrieved 2008.
• 3、 Mahato, Sachinta,Chatterjee, Rana,Chakraborty Ghosal, Nirnita,Majee, Adinath. "Zwitterionic imidazolium salt: An efficient organocatalyst for tetrahydropyranylation of alcohols". supporting information. p. 1905 - 1915. Retrieved 2017/10/07.
• 4、 Gharaati, Shadab,Kargar, Hadi,Falahati, Ali Mohammad. "Tetrahydropyranylation of alcohols and phenols catalyzed by a new multi-wall carbon nanotubes-bound tin(IV) porphyrin". . p. 1169 - 1178. Retrieved 2017/05/15.