Technology Process of C22H24FN3O
There total 7 articles about C22H24FN3O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-(3-fluorophenyl)propanal; 2-(acetamido)-6-(2-aminoethyl)quinoline;
With
magnesium sulfate; acetic acid;
In
methanol; chloroform;
at 20 ℃;
for 0.416667h;
With
sodium tris(acetoxy)borohydride;
In
methanol; chloroform;
at 0 - 20 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: borane-THF / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere
2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere
2.2: 1.25 h / -78 - 20 °C
3.1: acetic acid; magnesium sulfate / methanol; chloroform / 0.42 h / 20 °C
3.2: 0.5 h / 0 - 20 °C
With
borane-THF; oxalyl dichloride; magnesium sulfate; acetic acid; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; dichloromethane; chloroform;
DOI:10.1021/jm401838x
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 2.67 h / Inert atmosphere; Reflux
2.1: N,N-dimethyl-formamide / 17 h / 20 °C
3.1: hydrogen; ammonia / methanol; ethanol / 0.5 h
4.1: acetic acid; magnesium sulfate / methanol; chloroform / 0.42 h / 20 °C
4.2: 0.5 h / 0 - 20 °C
With
N-Bromosuccinimide; ammonia; hydrogen; magnesium sulfate; acetic acid; dibenzoyl peroxide;
In
methanol; ethanol; chloroform; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm401838x