1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline methiodide

Base Information

• Chemical Name: 1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline methiodide
• CAS No.: 77538-74-0
• Molecular Formula: C₂₁H₂₃N₂O₇*I
• Molecular Weight: 542.327
• Mol file: 77538-74-0.mol

Synonyms:1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline methiodide

Chemical Property of 1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline methiodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline methiodide

There total 3 articles about 1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline methiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2'-nitro-4',5'-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline (16251-41-5) → 1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline methiodide (77538-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / O₂ / Rose Bengal / methanol / Irradiation

2: acetone / 24 h / Heating

With oxygen; rose bengal; In methanol; acetone;

DOI:10.1016/S0040-4039(00)71477-8

Reference yield:

(4,5-dimethoxy-2-nitrophenyl)acetic acid (73357-18-3) → 1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline methiodide (77538-74-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / N,N'-carbonyldiimidazole / CH₂Cl₂ / 0 - 5 °C

2: 80 percent / Langheld ester (PPE) / CHCl₃ / 48 h / Heating

3: 82 percent / O₂ / Rose Bengal / methanol / Irradiation

4: acetone / 24 h / Heating

With ethyl metaphosphate; oxygen; 1,1'-carbonyldiimidazole; rose bengal; In methanol; dichloromethane; chloroform; acetone;

DOI:10.1016/S0040-4039(00)71477-8

Reference yield:

1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline (77513-48-5) + methyl iodide (74-88-4) → 1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline methiodide (77538-74-0)

Guidance literature:

In acetone; for 24h; Yield given; Heating;

DOI:10.1016/S0040-4039(00)71477-8

upstream raw materials:

1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline

methyl iodide

1-(2'-nitro-4',5'-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline

(4,5-dimethoxy-2-nitrophenyl)acetic acid

Downstream raw materials:

1-(2'-amino-4',5'-dimethoxy-α-oxobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Refernces