4-nitro-3-phenylbutanal

Base Information

• Chemical Name: 4-nitro-3-phenylbutanal
• CAS No.: 1002103-54-9
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.202
• Mol file: 1002103-54-9.mol

Synonyms:4-nitro-3-phenylbutanal

Chemical Property of 4-nitro-3-phenylbutanal

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-nitro-3-phenylbutanal

There total 10 articles about 4-nitro-3-phenylbutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

nitrostyrene (5153-67-3) + acetaldehyde (75-07-0,9002-91-9) → 4-nitro-3-phenylbutanal (1002103-54-9)

Guidance literature:

With (S)-α,α-diphenylprolinol trimethylsilyl ether supported onto superparamagnetic Fe3O4 nanoparticles; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1039/c1jm10535c

Reference yield: 45.0%

(E)-3-phenylpropenal (14371-10-9) + nitromethane (75-52-5) → 4-nitro-3-phenylbutanal (1002103-54-9) + 1-Nitro-4-phenyl-butadien (947740-50-3)

Guidance literature:

With piperazine functionalized graphene oxide; at 60 ℃; for 72h;

DOI:10.1039/c8ta03529f

Reference yield: 26.0%

(2-nitroethenyl)benzene (102-96-5) + isobutyraldehyde (78-84-2) → 4-nitro-3-phenylbutanal (1002103-54-9) + rac-2,2-dimethyl-4-nitro-3-phenylbutyraldehyde (93086-29-4)

Guidance literature:

With 4-oxalocrotonate tautomerase from Pseudomonas putida mt-2; In aq. phosphate buffer; ethanol; at 28 ℃; for 4h; pH=7.2; Enzymatic reaction;

DOI:10.1039/c4ra05517a

upstream raw materials:

(E)-3-phenylpropenal

nitromethane

3-phenyl-propenal

nitrostyrene

Downstream raw materials:

(S)-4-nitro-3-phenylbutan-1-ol

(R)-4-nitro-3-phenylbutan-1-ol

3-[3-(2-hydroxyphenyl)-3-oxoprop-1-enyl]-4H-chromen-4-one

Refernces

• 1、 Zandvoort, Ellen,Geertsema, Edzard M.,Baas, Bert-Jan,Quax, Wim J.,Poelarends, Gerrit J.. "An Unexpected Promiscuous Activity of 4-Oxalocrotonate Tautomerase: The cis-trans Isomerisation of Nitrostyrene". . p. 1869 - 1873. Retrieved 2012.
• 2、 Anderson, James C.,Bouvier-Israel, Eva,Rundell, Christopher D.,Zhang, Xiangyu. "Asymmetric synthesis of piperidines using the nitro-Mannich reaction☆". . . Retrieved 2020/12/21.
• 3、 -. "A class of polysubstituted benzene compounds and synergistic catalytic preparation method thereof". Paragraph 0130; 0131. . Retrieved 2020/04/02.