N-(4-methylphenyl)thioformamide

Base Information

• Chemical Name: N-(4-methylphenyl)thioformamide
• CAS No.: 26060-31-1
• Molecular Formula: C₈H₉NS
• Molecular Weight: 151.232
• Mol file: 26060-31-1.mol

Synonyms:N-(4-methylphenyl)thioformamide

Chemical Property of N-(4-methylphenyl)thioformamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methylphenyl)thioformamide

There total 5 articles about N-(4-methylphenyl)thioformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-isothiocyanato-4-methylbenzene (622-59-3) → N-(4-methylphenyl)thioformamide (26060-31-1)

Guidance literature:

With zirconocene dichloride; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; 2-methyltetrahydrofuran; at 0 - 20 ℃; chemoselective reaction; Green chemistry;

DOI:10.1039/c8ob02312c

Reference yield: 73.0%

N-(4-methylphenyl)formamide (3085-54-9) → N-(4-methylphenyl)thioformamide (26060-31-1)

Guidance literature:

With tetraphosphorus decasulfide; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 24h;

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + p-toluidine (106-49-0,12221-03-3) → N-(4-methylphenyl)thioformamide (26060-31-1)

Guidance literature:

carbon disulfide; p-toluidine; With triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With dmap; In tetrahydrofuran; for 0.0833333h; Inert atmosphere; Cooling with ice;

upstream raw materials:

N-(4-methylphenyl)formamide

1-isothiocyanato-4-methylbenzene

carbon disulfide

p-toluidine

Downstream raw materials:

1-(p-tolyl)-1,2,3,4-tetrazole

N,N'-di-p-tolylformamidine

Refernces

• 1、 -. "Compound comprising urea and thiourea structures and synthesis method and application of compound". Paragraph 0064-0065. . Retrieved 2019/08/07.