Ethyl 2-amino-4-methylthiophene-3-carboxylate

Base Information

• Chemical Name: Ethyl 2-amino-4-methylthiophene-3-carboxylate
• CAS No.: 43088-42-2
• Molecular Formula: C8H11NO2S
• Molecular Weight: 185.247
• Hs Code.: 29349990
• Mol file: 43088-42-2.mol

Synonyms:2-Amino-3-ethoxycarbonyl-4-methylthiophene;2-Amino-4-methylthiophene-3-carboxylic acid ethyl ester;Ethyl2-amino-4-methyl-3-thiophenecarboxylate;

Chemical Property of Ethyl 2-amino-4-methylthiophene-3-carboxylate

Chemical Property:

• Vapor Pressure: 0.00411mmHg at 25°C
• Melting Point: 80 °C
• Refractive Index: 1.573
• Boiling Point: 279.1 °C at 760 mmHg
• PKA: 0.24±0.10(Predicted)
• Flash Point: 122.6 °C
• PSA: 80.56000
• Density: 1.22 g/cm³
• LogP: 2.39660
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water

Purity/Quality:

98% ^*data from raw suppliers

Ethyl 2-Amino-4-methylthiophene-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-amino-4-methylthiophene-3-carboxylate

There total 7 articles about Ethyl 2-amino-4-methylthiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 2-amino-4-methyl-5-(tert-butoxycarbonyl)thiophene-3-carboxylate → 2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester (43088-42-2)

Guidance literature:

With hydrogenchloride; In ethanol; for 1h; Heating;

DOI:10.1021/jm991108w

Reference yield: 76.0%

ethyl 2-cyanoacetate (105-56-6) + acetone (67-64-1) → 2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester (43088-42-2)

Guidance literature:

With morpholine; sulfur; In ethanol; at 90 ℃;

DOI:10.1016/j.bmcl.2012.04.109

Reference yield: 50.0%

morpholine (110-91-8,99108-56-2) + ethyl 2-cyanoacetate (105-56-6) + acetone (67-64-1) → 2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester (43088-42-2) + ethyl 2-amino-5-morpholino-4-methylthiophene-3-carboxylate

Guidance literature:

With sulfur; In ethanol; for 4h; Reflux;

DOI:10.1039/c4ob00175c

upstream raw materials:

ethyl 2-cyanoacetate

acetone

diethylamine

morpholine

Downstream raw materials:

2-[3-(3,4-Dichloro-benzyl)-ureido]-4-methyl-thiophene-3-carboxylic acid ethyl ester

2-(3-chloromethylbenzoylamino)-4-methyl-thiophene-3-carboxylic acid ethyl ester

2-mercapto-3-(4-methoxy-phenyl)-5-methyl-3H-thieno[2,3-d]pyrimidin-4-one

2-[3-(4-Bromo-2-fluoro-benzyl)-ureido]-4-methyl-thiophene-3-carboxylic acid ethyl ester

Refernces

• 1、 -. "HISTONE METHYLTRANSFERASE EZH2 INHIBITOR, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF". Paragraph 0446-0447. . Retrieved 2019/11/22.
• 2、 Flood, Aoife,Trujillo, Cristina,Sanchez-Sanz, Goar,Kelly, Brendan,Muguruza, Carolina,Callado, Luis F.,Rozas, Isabel. "Thiophene/thiazole-benzene replacement on guanidine derivatives targeting α2-Adrenoceptors". supporting information. p. 38 - 50. Retrieved 2017/06/23.