4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide

Base Information

• Chemical Name: 4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide
• CAS No.: 92-76-2
• Molecular Formula: C18H14ClNO2
• Molecular Weight: 311.768
• Hs Code.: 2924299090
• European Community (EC) Number: 202-187-6
• NSC Number: 59807,50686
• UNII: 3P5BHY5UDZ
• DSSTox Substance ID: DTXSID2059065
• Nikkaji Number: J73.254K
• Wikidata: Q72451876
• Mol file: 92-76-2.mol

Synonyms:92-76-2;4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide;n-(4-chloro-2-methylphenyl)-3-hydroxy-2-naphthamide;Naphthol AS-TR;Naphtanilide TR;Naphthoide TR;Azoground TR;Naphtazol TR;Solunaptol CTL;Solunaptol CTX;Brenthol CT;Acna Naphthol T;Cibanaphthol RCT;Sanatol TR;Naftolo MTR;Amarthol AS-TR;Tulathol AS-TR;Naphtol AS-TR;Daito Grounder TR;Naphtol AS-TRLL;Azoic Coupling Component 8;Anthonaphthol AS-TR;Naphtol AS-TR Supra;N-(4-chloro-2-methylphenyl)-3-hydroxynaphthalene-2-carboxamide;Amanil Naphthol AS-TR;Naphthol AS-TR Dispersible;2-Naphthalenecarboxamide, N-(4-chloro-2-methylphenyl)-3-hydroxy-;C.I. 37525;C.I. Azoic Coupling Component 8;3P5BHY5UDZ;2-Naphtho-o-toluidide, 4'-chloro-3-hydroxy-;EINECS 202-187-6;NSC 50686;NSC-50686;4'-chloro-3-hydroxy-2-naphtho-o-toluidide;UNII-3P5BHY5UDZ;NCIOpen2_007776;SCHEMBL825861;DTXSID2059065;AMY31438;N-(4-chloro-2-methyl-phenyl)-3-hydroxy-naphthalene-2-carboxamide;NSC50686;NSC59807;MFCD00021638;NSC-59807;2,2-diethoxyethylsulfanylmethylbenzene;AKOS003381950;s12002;C.I.37525;CS-0321823;FT-0631455;4'-chlor-3-hydroxy-2'-methyl-2-naphthanilid;3-hydroxy-2-naphthoic 4-chloro-2-methylanilide;4\'-Chloro-3-hydroxy-2\'-methyl-2-naphthanilide;A844331;N-(4-Chloro-2-methylphenyl)-3-hydroxy-2-naphthalenecarboxamide;5-BROMO-6-CHLORO-3-INDOLYLBETA-D-GLUCURONIDECYCLOHEXYLAMMONIUMSALT

Chemical Property of 4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide

Chemical Property:

• Vapor Pressure: 7.31E-08mmHg at 25°C
• Refractive Index: 1.717
• Boiling Point: 426.1 °C at 760 mmHg
• Flash Point: 211.5 °C
• PSA: 49.33000
• Density: 1.36 g/cm³
• LogP: 4.83250
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 311.0713064
• Heavy Atom Count: 22
• Complexity: 403

Purity/Quality:

99% ^*data from raw suppliers

4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)Cl)NC(=O)C2=CC3=CC=CC=C3C=C2O

Technology Process of 4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide

There total 2 articles about 4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Hydroxy-2-naphthoic acid (92-70-6) + 4-chloro-2-methylbenzeneamine (95-69-2) → naphthol ASTR (92-76-2)

Guidance literature:

With toluene; phosphorus trichloride;

Reference yield:

→ naphthol ASTR (92-76-2)

Guidance literature:

3-Hydroxy-<2>naphthoesaeure, 1) SOCl2, (65-70grad), 2) 4-Chlor-2-methyl-anilin, aq. Na2CO3, Benzol, (80-85grad);

Reference yield: 74.0%

naphthol ASTR (92-76-2) + 11-amino-3-bromo-13H-acenaphtho[1,2-e]pyridazino[3,2-b]quinazoline-13-one (443288-66-2) → C39H22BrClN6O3

Guidance literature:

11-amino-3-bromo-13H-acenaphtho[1,2-e]pyridazino[3,2-b]quinazoline-13-one; With hydrogenchloride; sodium nitrite; at 0 - 5 ℃;

naphthol ASTR; In alkaline aq. solution; at 0 - 5 ℃;

DOI:10.1515/HC.2001.7.6.599

upstream raw materials:

3-Hydroxy-2-naphthoic acid

4-chloro-2-methylbenzeneamine

Downstream raw materials:

3-(4-chloro-2-methyl-phenyl)-naphtho[2,3-e][1,3]oxazine-2,4-dione

Phosphoric acid mono-[3-(4-chloro-2-methyl-phenylcarbamoyl)-naphthalen-2-yl] ester

Refernces