Guanfacine hydrochloride

Base Information Edit

Chemical Name:Guanfacine hydrochloride
CAS No.:29110-48-3
Molecular Formula:C9H9 Cl2 N3 O . Cl H
Molecular Weight:282.557
Hs Code.:2925294500
European Community (EC) Number:249-443-3
NSC Number:759121
UNII:PML56A160O
DSSTox Substance ID:DTXSID2045157
Wikidata:Q27286641
NCI Thesaurus Code:C47550
RXCUI:203142
ChEMBL ID:CHEMBL1200494
Mol file:29110-48-3.mol

Synonyms:BS 100 141;BS-100-141;BS100141;Estulic;Guanfacine;Guanfacine Hydrochloride;Guanfacine Monohydrochloride;Hydrochloride, Guanfacine;Lon798;Monohydrochloride, Guanfacine;Tenex

Suppliers and Price of Guanfacine hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Guanfacine hydrochloride
10mg
$ 310.00

TRC
Guanfacine hydrochloride
25mg
$ 100.00

Tocris
Guanfacine hydrochloride ≥99%(HPLC)
10
$ 87.00

Tocris
Guanfacine hydrochloride ≥99%(HPLC)
50
$ 309.00

TCI Chemical
Guanfacine Hydrochloride >98.0%(HPLC)(T)
1g
$ 420.00

TCI Chemical
Guanfacine Hydrochloride >98.0%(HPLC)(T)
100mg
$ 66.00

Sigma-Aldrich
Guanfacine hydrochloride ≥98% (HPLC)
10mg
$ 52.70

Sigma-Aldrich
Guanfacine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material
500mg
$ 133.00

Sigma-Aldrich
Guanfacine hydrochloride United States Pharmacopeia (USP) Reference Standard
125mg
$ 297.00

Sigma-Aldrich
Guanfacine hydrochloride ≥98% (HPLC)
50mg
$ 231.00

Total 98 raw suppliers

Chemical Property of Guanfacine hydrochloride Edit

Chemical Property:

Melting Point:215-217℃
PSA：78.97000
LogP:3.53850
Storage Temp.:Store at RT
Solubility.:H2O: 12 mg/mL at 60 °C, soluble
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:280.988945
Heavy Atom Count:16
Complexity:256

Purity/Quality:

99% ^*data from raw suppliers

Guanfacine hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl
Recent ClinicalTrials:A Study of TAK-503 in Children and Teenagers With Attention Deficit Hyperactivity Disorder (ADHD)
Recent EU Clinical Trials:A Phase 4, Multicenter, 2-part Study Composed of a 1-Year Randomized, Double-blind, Parallel-group, Placebo-controlled, Active-comparator, Dose-optimization Evaluation followed by a 1-Year Open-label Evaluation to Assess the Safety and Efficacy of Guanfacine Hydrochloride
Uses Guanfacine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by spectrophotometry and high performance liquid chromatography. Antihypertensor;Alpha 2A agonist Centrally acting a-adrenoceptor agonist. Antihypertensive
Therapeutic Function Antihypertensive
Clinical Use Overall, the therapeutic applications for guanfacine are similar to those of the other centrally acting α2-adrenergic agonists and methyldopa. It has been effective as monotherapy in the treatment of patients with mild to moderate hypertension. One advantage for guanfacine is its once-a-day dosing schedule. The use of diuretics to prevent accumulation of fluid may allow a reduction in the dosage for guanfacine.

Technology Process of Guanfacine hydrochloride

There total 2 articles about Guanfacine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%