Congo red

Base Information

• Chemical Name: Congo red
• CAS No.: 573-58-0
• Deprecated CAS: 550-08-3,70248-72-5,87440-95-7,1000818-40-5,1000818-40-5,70248-72-5,87440-95-7
• Molecular Formula: C32H22N6Na2O6S2
• Molecular Weight: 696.675
• Hs Code.: DERIVATION
• European Community (EC) Number: 209-358-4
• UNII: 3U05FHG59S
• DSSTox Substance ID: DTXSID4022816
• Nikkaji Number: J6.549H
• Wikipedia: Congo_red
• Wikidata: Q114391
• NCI Thesaurus Code: C81102
• Pharos Ligand ID: 1CWNDMC3AH2J
• ChEMBL ID: CHEMBL429694
• Mol file: 573-58-0.mol

Synonyms:Congo Red;Red, Congo

Chemical Property of Congo red

Chemical Property:

• Appearance/Colour: brown-red powder
• Vapor Pressure: <1 Pa
• Melting Point: >360 °C(lit.)
• PKA: 4.1(at 25℃)
• PSA: 232.64000
• Density: 0.995 g/mL at 25 °C
• LogP: 10.78740
• Storage Temp.: Flammables area
• Solubility.: H2O: soluble10mg/mL
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 5
• Exact Mass: 696.08376335
• Heavy Atom Count: 48
• Complexity: 1180

Purity/Quality:

99% ^*data from raw suppliers

Direct Red 28 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, Xi
• Hazard Codes: T,Xi
• Statements: 45-63-36
• Safety Statements: 53-45-37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Dyes -> Benzidine Dyes
• Canonical SMILES: C1=CC=C2C(=C1)C(=CC(=C2N)N=NC3=CC=C(C=C3)C4=CC=C(C=C4)N=NC5=C(C6=CC=CC=C6C(=C5)S(=O)(=O)[O-])N)S(=O)(=O)[O-].[Na+].[Na+]
• Recent NIPH Clinical Trials: Role of cellular senescence in gastric carcinogenesis after eradication of Helicobacter pylori
• Uses: 1. It has been widely used in cotton, viscose dyeing. Because it can easily be transformed into blue when in acid, while there is no appropriate treatment to improve, the usage amount is gradually decreased since the advent of insoluble azo dyes and acid-resistant red 4BS, however, the amount used in the paper industry is quite large. It can also be used as indicators of acid-base, namely Congo red test paper. The measurable range pH is 3.0 (blue)-5.0 (red). It is also used for biological staining, analysis reagents. 2. An indicator frequently used in lab as well as a carcinogenic disperse dyes; used to standard test. 3. Used as an acid-base indicator, adsorption indicator and biological stain, etc. 4. Acid-base indicator, pH 3.0 (blue violet)~5.0 (red); detect the acidity of paper and hydrochloric acid in the gastric juice; test boric acid, cyanide; biological media additives; biological staining, such as embryo slices, plant mucin, cellulose, elastic tissue dyeing. 5. Mainly used for dyeing cotton, hemp, silk and other textile and paper products; it can also be used as an indicator. Dye, medicine (diagnostic aid), indicator, biological stain. Congo red is useful for staining and visual detection of amyloid deposits. It inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the metabolism of the normal isoform. Congo red has been used as a histochemical stain for the quantification of amyloid deposits in brain tissues. It has been used as a cell wall inhibiting agent in fungus Cryptococcus neoformans. It has also been used to study microstructural details in the cell walls of raw potato and fried potato using confocal microscopy.

Technology Process of Congo red

There total 2 articles about Congo red which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ congo red (573-58-0)

Guidance literature:

Herstellung des Dinatrium-Salzes der 4,4'-Diamino-3,3'-iphenyl-4,4'-diylbisazo-bis-naphthalin-1-<³⁵S>sulfonsaeure;

Reference yield:

sodium naphthionate + p,p'-diaminobiphenyl (92-87-5) → Brasilamina Congo 4B (573-58-0)

Guidance literature:

p,p'-diaminobiphenyl; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃; for 1h;

sodium naphthionate; In water; at 0 - 5 ℃;

Reference yield: 85.0%

[Zn(1,2,3-benzenetricarboxylate)(H2O)](H2-N,N'-di(3-pyridyl)succinamide)0.5*2H2O + congo red (573-58-0) → [Zn(1,2,3-benzenetricarboxylate)(H2O)](H2-N,N'-di(3-pyridyl)succinamide)0.5*0.75(Congo Red)*6H2O

Guidance literature:

In water; for 2h;

DOI:10.1039/c5cc05990a

upstream raw materials:

p,p'-diaminobiphenyl

Downstream raw materials:

3,4-diamino-naphthalene-1-sulphonic acid

p,p'-diaminobiphenyl

3,4-dioxo-3,4-dihydro-naphthalene-1-sulfonic acid

biphenyl

Refernces