Leucylarginine

Base Information

• Chemical Name: Leucylarginine
• CAS No.: 26607-15-8
• Molecular Formula: C₁₂H₂₅N₅O₃
• Molecular Weight: 287.362
• DSSTox Substance ID: DTXSID20949447
• Nikkaji Number: J151.282J
• Wikidata: Q27140610
• Metabolomics Workbench ID: 78857
• Mol file: 26607-15-8.mol

Synonyms:L-leucyl-L-arginine;Leu-Arg;leucyl-arginine;leucylarginine

Chemical Property of Leucylarginine

Chemical Property:

• Refractive Index: 1.58
• PSA: 154.32000
• Density: 1.33 g/cm³
• LogP: 1.47460
• Storage Temp.: -15°C
• XLogP3: -4
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 287.19573968
• Heavy Atom Count: 20
• Complexity: 353

Purity/Quality:

98%Min ^*data from raw suppliers

H-Leu-Arg-OHacetatesalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)O)N
• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N

Technology Process of Leucylarginine

There total 5 articles about Leucylarginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Leu-Arg → LR (26607-15-8,38062-60-1,93220-84-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In water; at 43 ℃;

Reference yield:

Leu-Arg-MCA (929622-05-9) → LR (26607-15-8,38062-60-1,93220-84-9)

Guidance literature:

With ethylenediaminetetraacetic acid; dipeptydyl-peptidase DPP₃; sodium phosphate; sodium chloride; In water; at 37 ℃; for 0.5h; pH=7.0; Reagent/catalyst; Catalytic behavior; Enzymatic reaction;

DOI:10.1074/jbc.M113.527333

Reference yield:

Z-L-leucine hydroxysuccinimide ester (3397-35-1) → LR (26607-15-8,38062-60-1,93220-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 24 h

2: palladium on activated charcoal; hydrogen / water / 43 °C

With palladium on activated charcoal; hydrogen; In water; N,N-dimethyl-formamide;

upstream raw materials:

Leu-Arg-MCA

Z-L-leucine hydroxysuccinimide ester

L-arginine

Refernces

• 1、 Ohara-Nemoto, Yuko,Rouf, Shakh M. A.,Naito, Mariko,Yanase, Amie,Tetsuo, Fumi,Ono, Toshio,Kobayakawa, Takeshi,Shimoyama, Yu,Kimura, Shigenobu,Nakayama, Koji,Saiki, Keitarou,Konishi, Kiyoshi,Nemoto, Takayuki K.. "Identification and characterization of prokaryotic dipeptidyl-peptidase 5 from porphyromonas gingivalis". . p. 5436 - 5448. Retrieved 2014/03/21.