Girard's reagent T

Base Information

• Chemical Name: Girard's reagent T
• CAS No.: 123-46-6
• Deprecated CAS: 113079-22-4
• Molecular Formula: C5H14N3O^.Cl
• Molecular Weight: 167.639
• Hs Code.: 29280000
• European Community (EC) Number: 204-629-3
• NSC Number: 9242
• UNII: OO3MF0US46
• DSSTox Substance ID: DTXSID00883315
• Wikidata: Q27285753
• Mol file: 123-46-6.mol

Synonyms:(carboxymethyl)trimethylammonium chloride hydrazide;betaine hydrazide hydrochloride;Girard reagent;Girard reagent T;Girard's reagent T

Chemical Property of Girard's reagent T

Chemical Property:

• Appearance/Colour: white to almost white crystalline powder
• Melting Point: 188-192 °C (dec.)(lit.)
• Refractive Index: 1.5400 (estimate)
• PSA: 55.12000
• Density: 1.3799 (rough estimate)
• LogP: -3.22230
• Storage Temp.: Flammables area
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 167.0825398
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

99%min. ^*data from raw suppliers

Girard’s reagent T ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,F
• Hazard Codes: Xn-F,Xn,F
• Statements: 44-36/37/38-20/22-11-R44-R36/37/38-R20/22-R11
• Safety Statements: 22-24/25-36/37/39-26-16-S36/37/39-S26-S16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+](C)(C)CC(=O)NN.[Cl-]
• Uses: Girard''s Reagent T is a derivatizing agent used to generate permanent cationic charge at the reducing ends of neutral oligosaccharides for easier quantification in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Girard′s reagent T may be used as a derivatizing reagent for the determination of 5-Formyl-2′-deoxyuridine in cellular DNA samples using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique. Reducing saccharides can be derivatized by Girard′s reagent T and this can be analyzed by matrix-assisted laser desorption/ionization coupled to time of flight mass spectrometry (MALDI-TOF-MS) technique.

Technology Process of Girard's reagent T

There total 25 articles about Girard's reagent T which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-benzylidenehydrazinyl)-N,N,N-trimethyl-2-oxoethaneaminium chloride (6958-22-1) → girard's reagent T (123-46-6) + benzaldehyde (100-52-7)

Guidance literature:

In water; at 25 ℃; Equilibrium constant;

DOI:10.1021/jo00004a016

Reference yield:

[1-Biphenyl-4-yl-meth-(Z)-ylidene-hydrazinocarbonylmethyl]-trimethyl-ammonium; chloride → girard's reagent T (123-46-6) + 4-Phenylbenzaldehyde (3218-36-8)

Guidance literature:

In water; at 25 ℃; Equilibrium constant;

DOI:10.1021/jo00004a016

Reference yield:

Trimethyl-[1-(4-nitro-phenyl)-meth-(Z)-ylidene-hydrazinocarbonylmethyl]-ammonium; chloride → girard's reagent T (123-46-6) + 4-nitrobenzaldehdye (555-16-8)

Guidance literature:

In water; at 25 ℃; Equilibrium constant;

DOI:10.1021/jo00004a016

upstream raw materials:

Carboxymethyl-trimethyl-ammonium-chlorid-

2-(2-benzylidenehydrazinyl)-N,N,N-trimethyl-2-oxoethaneaminium chloride

Trimethyl-[1-p-tolyl-meth-(E)-ylidene-hydrazinocarbonylmethyl]-ammonium; chloride

anisaldehyde carbohydrazone methyl trimethyl ammonium chloride

Downstream raw materials:

trimethyl-([2]thienylmethylenehydrazinocarbonyl-methyl)-ammonium; chloride

(trans-cinnamylidenehydrazinocarbonyl-methyl)-trimethyl-ammonium; chloride

Trimethyl-[1-p-tolyl-meth-(E)-ylidene-hydrazinocarbonylmethyl]-ammonium; chloride

Carboxymethyl-trimethyl-ammonium-chlorid-

Refernces

• 1、 Higgs, Patrick L.,Ruiz-Sanchez, Antonio J.,Dalmina, Milene,Horrocks, Benjamin R.,Leach, Andrew G.,Fulton, David A.. "Enhancing the kinetics of hydrazone exchange processes: An experimental and computational study". supporting information. p. 3218 - 3224. Retrieved 2019/03/26.
• 2、 Levrand, Barbara,Ruff, Yves,Lehn, Jean-Marie,Herrmann, Andreas. "Controlled release of volatile aldehydes and ketones by reversible hydrazone formation - "Classical" profragrances are getting dynamic". . p. 2965 - 2967. Retrieved 2008/09/20.