C₁₂H₁₅N⁽¹⁸⁾O

Base Information

• Chemical Name: C₁₂H₁₅N⁽¹⁸⁾O
• CAS No.: 1373313-66-6
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 191.258
• Mol file: 1373313-66-6.mol

Synonyms:C₁₂H₁₅N⁽¹⁸⁾O

Chemical Property of C₁₂H₁₅N⁽¹⁸⁾O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₂H₁₅N⁽¹⁸⁾O

There total 3 articles about C₁₂H₁₅N⁽¹⁸⁾O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

di(piperidin-1-yl)methanethione (1013-92-9) + phenylboronic acid (98-80-6) → C12H15N(18)O (1373313-66-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; ¹⁸O-labeled water; silver carbonate; In 2,2,2-trifluoroethanol; at 90 ℃; for 4h;

DOI:10.1002/cctc.202001099

Reference yield:

N-Benzylpiperidine (2905-56-8) → C12H15N(18)O (1373313-66-6)

Guidance literature:

With DBN; rose bengal; oxygen-18; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Irradiation;

DOI:10.1021/acscatal.8b01897

Reference yield:

piperidine (110-89-4) + [18O]-benzaldehyde (55076-26-1) → C12H15N(18)O (1373313-66-6)

Guidance literature:

With potassium tetrachloroaurate(III); potassium carbonate; In H₂⁽¹⁸⁾O; at 40 ℃; for 12h;

DOI:10.1039/c2cc17689k

upstream raw materials:

piperidine

[¹⁸O]-benzaldehyde

N-Benzylpiperidine

di(piperidin-1-yl)methanethione

Refernces

• 1、 Zhang, Yu,Riemer, Daniel,Schilling, Waldemar,Kollmann, Jiri,Das, Shoubhik. "Visible-Light-Mediated Efficient Metal-Free Catalyst for α-Oxygenation of Tertiary Amines to Amides". . p. 6659 - 6664. Retrieved 2018/06/25.