N-Phenylacetyl-N'-formylhydrazin

Base Information

• Chemical Name: N-Phenylacetyl-N'-formylhydrazin
• CAS No.: 22261-06-9
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.191
• Mol file: 22261-06-9.mol

Synonyms:N-Phenylacetyl-N'-formylhydrazin

Chemical Property of N-Phenylacetyl-N'-formylhydrazin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-Phenylacetyl-N'-formylhydrazin

There total 1 articles about N-Phenylacetyl-N'-formylhydrazin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

formyl acetic anhydride (2258-42-6) + 2-phenylacetylhydrazine (937-39-3) → N-Phenylacetyl-N'-formylhydrazin (22261-06-9)

Guidance literature:

With formic acid; In water; for 0.5h;

DOI:10.1055/s-1991-26588

Reference yield: 73.0%

N-Phenylacetyl-N'-formylhydrazin (22261-06-9) + Methyl benzenesulfonate (80-18-2) → C11H14N2O2 (138211-80-0)

Guidance literature:

With sodium hydroxide; In water; at 90 ℃; for 0.5h;

DOI:10.1055/s-1991-26588

Reference yield:

N-Phenylacetyl-N'-formylhydrazin (22261-06-9) → 1,2-Dimethyl-4-phenyl-1,2-dihydro-pyrazol-3-one (138211-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / 40percent NaOH / H₂O / 0.5 h / 90 °C

2: 94 percent / LiN(SiMe₃)2, TMEDA / tetrahydrofuran / 1) -78 deg C, 30 min, 2) RT, 3) 60 min, reflux

With sodium hydroxide; N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane; In tetrahydrofuran; water;

DOI:10.1055/s-1991-26588

upstream raw materials:

formyl acetic anhydride

2-phenylacetylhydrazine

Downstream raw materials:

C₁₁H₁₄N₂O₂

1,2-Dimethyl-4-phenyl-1,2-dihydro-pyrazol-3-one

Refernces