3,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 3,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate
• CAS No.: 1203549-54-5
• Molecular Formula: C₁₂H₁₇F₃O₅SSi
• Molecular Weight: 358.411
• Mol file: 1203549-54-5.mol

Synonyms:3,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate

Chemical Property of 3,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate

There total 2 articles about 3,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + C11H17BrO3Si → 3,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate (1203549-54-5)

Guidance literature:

C₁₁H₁₇BrO₃Si; With n-butyllithium; In tetrahydrofuran; hexane; at -100 - -82 ℃; Inert atmosphere;

trifluoromethylsulfonic anhydride; In tetrahydrofuran; hexane; at -100 - -80 ℃; Inert atmosphere;

DOI:10.1021/ol1000796

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + 2-(trimethylsilyl)-3,5-dimethoxyphenyl trimethylsilyl ether → 3,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate (1203549-54-5)

Guidance literature:

2-(trimethylsilyl)-3,5-dimethoxyphenyl trimethylsilyl ether; With n-butyllithium; In diethyl ether; Inert atmosphere;

trifluoromethylsulfonic anhydride; In diethyl ether; Inert atmosphere;

DOI:10.1246/cl.2010.508

Reference yield: 86.0%

3,5-dimethoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate (1203549-54-5) + sodium phenylsulfonate (515-42-4) → 1,3-dimethoxy-5-(phenylsulfonyl)benzene (1617534-58-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol5018646

upstream raw materials:

trifluoromethylsulfonic anhydride

Downstream raw materials:

2-acetyl-3,5-dimethoxyphenylacetic acid methyl ester

O,O-Dimethyl-curvulin

ethyl 2-(3,5-dimethoxy-2-octanoylphenyl)acetate

C₂₆H₂₇NO₄

Refernces

• 1、 Tadross, Pamela M.,Gilmore, Christopher D.,Bugga, Pradeep,Virgil, Scott C.,Stoltz, Brian M.. "Regioselective reactions of highly substituted arynes". supporting information; experimental part. p. 1224 - 1227. Retrieved 2010/06/13.