1-(3-methoxy-4-methylphenyl)-2-nitropropene

Base Information

• Chemical Name: 1-(3-methoxy-4-methylphenyl)-2-nitropropene
• CAS No.: 132980-18-8
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 132980-18-8.mol

Synonyms:1-(3-methoxy-4-methylphenyl)-2-nitropropene

Chemical Property of 1-(3-methoxy-4-methylphenyl)-2-nitropropene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(3-methoxy-4-methylphenyl)-2-nitropropene

There total 1 articles about 1-(3-methoxy-4-methylphenyl)-2-nitropropene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

Nitroethane (79-24-3) + 3-methoxy-4-methylbenzaldehyde (24973-22-6) → 1-(3-methoxy-4-methylphenyl)-2-nitropropene (132980-18-8)

Guidance literature:

With ammonium acetate; for 2.5h; Heating;

DOI:10.1021/jm00109a020

Reference yield: 53.4%

1-(3-methoxy-4-methylphenyl)-2-nitropropene (132980-18-8) → 1-(3-methoxy-4-methylphenyl)-2-propanone (51814-28-9)

Guidance literature:

With sodium dihydrogenphosphate; acetate buffer; W-2 Raney Ni; In ethanol; at 40 ℃; for 1.5h; Irradiation;

DOI:10.1021/jm00109a020

Reference yield:

1-(3-methoxy-4-methylphenyl)-2-nitropropene (132980-18-8) → [(S)-2-(3-Methoxy-4-methyl-phenyl)-1-methyl-ethyl]-((S)-1-phenyl-ethyl)-amine

Guidance literature:

Multi-step reaction with 2 steps

1: 53.4 percent / 0.2 M aq. acetate buffer (pH 5), NaH₂PO₄ / W-2 Raney Ni / aq. ethanol / 1.5 h / 40 °C / Irradiation

2: 2.) H₂ / 2.) W₂ Raney Ni / 1.) benzene, reflux, 2 h, 2.) EtOH, 50 psi, 24 h

With sodium dihydrogenphosphate; acetate buffer; hydrogen; W-2 Raney Ni; W₂ Raney Ni; In ethanol;

DOI:10.1021/jm00109a020

upstream raw materials:

Nitroethane

3-methoxy-4-methylbenzaldehyde

Downstream raw materials:

1-(3-methoxy-4-methylphenyl)-2-propanone

1-(3-methoxy-4-methyl-phenyl)propan-2-amine

Refernces